Sinulasterols A–C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa

Marine natural products

“…), 588 acutumosterols A 1345 and B 1346 (Sarcophyton acutum), 589 yalongsterol A 1347 (Sinularia sp. ), 590 sinulasterols A-C 1348-1350 (Sinularia depressa), 591 and six new examples 1351-1356 from a Red Sea collection of Sinularia polydactyla. 592 The functional and ecological context 593 and therapeutic potential 594 of cnidarian toxins have been reviewed.…”

Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013

“…Three new oxygenated steroids, sinulasterols A-C (226-228), were isolated from the Chinese soft coral S. depressa [5]. Compounds 226 and 228 featured unusual C-18 oxygenated patterns.…”

“…Compounds 226 and 228 featured unusual C-18 oxygenated patterns. In the TNF-α bioassay, 226 and 227 displayed a moderate inhibitory activity [5].…”

“…As reported, Sinularia is well-known to produce a wealth of diverse and com plex secondary metabolites, such as sesquiterpenes (10%), diterpenes (46%), norsesqui erpenes (2%), norditerpenes (9%), steroids/steroidal glycosides (22%), and other type (11%) (Figure 1) [1][2][3]. These metabolites exhibit a wide range of biological activities, suc as cytotoxic, anti-inflammatory, antifouling, and anti-microbials [4][5][6][7][8][9][10][11][12][13][14]. There are some published literature reviews on the genus Sinularia.…”

Uncommon Polycyclic Merosesquiterpenoids and Asteriscanoids from the Hainan Soft Coral Sinularia humesi†

“…[ 1‐2 ] To date, more than 500 secondary metabolites belonging to various structural classes have been discovered from approximately 50 species of Sinularia . [ 2 ] Many metabolites such as sesquiterpenoids, [ 3 ] diterpenoids, [ 4 ] steroids, [ 5 ] etc ., exhibited a wide spectrum of biological activities ranging from cytotoxic, [ 4,6 ] anti‐inflammatory, [ 3‐4,7 ] immunosuppressive, [ 8 ] to antifouling [ 9‐10 ] effects.…”