Sintered dicalcium pyrophosphate decreases bone turnover rate in osteoporotic rat: A study on serum biochemical bone turnover markers

The Antiosteoporotic Effects of Cheonggukjang Containing Vitamin K2 (Menaquinone-7) in Ovariectomized Rats

“…In some studies, they had demonstrated that CGJ and other antiosteoporotic materials reduced serum osteocalcin levels in OVX rats, which in turn decreased the rate of bone metabolism. 21,25,27 Some other studies indicated that feeding of genistein (a soybeanderived isoflavone) increased the serum osteocalcin level and the bone formation in OVX rats. 26,28 In contrast to these studies, other researchers also reported that materials with antiosteoporotic effects had no influence on serum osteocalcin, 15,18 which are similar to the present study.…”

“…1), which was in agreement with previous studies. [19][20][21] Ovariectomy-induced weight gain can be reversed by estrogen replacement and can also be prevented by administrating with soybean proteins or isoflavones in rats. 19,20,22 However, in this study, drug administration did not affect the body weight growth patterns, suggesting that the action mechanisms of MK-7 and CGJ are different from estrogen-like compounds.…”

“…Osteocalcin is a noncollagenous protein secreted by osteoblasts that participates in mineralization and calcium ion homeostasis; therefore, it can be implicated as an important indicator of bone formation. 21 Osteocalcin level increases during the process of bone degradation. 25 The serum osteocalcin levels in rats from the OVX group were significantly higher than those in the Sham group (Table 1), and this phenomenon was not significantly affected by administration of MK-7 or CGJ.…”

Marrow adipogenesis and bone loss that parallels estrogen deficiency is slowed by low-intensity mechanical signals

“…Alkaline phosphatase, a protein secreted by osteoblasts and associated with osteoid formation and mineralization [36], has been shown to increase 1 week after ovariectomy. However, these transient elevations are overwhelmed by the increase in TRAP5b levels, which increase immediately after OVX and persist for longer [37] before normalizing to baseline levels by 2w [37,27,38,39].…”

Better Osteoporotic Fracture Healing with Sintered Dicalcium Pyrophosphate (SDCP) Treatment

“…SDCP may either influence bone resorption by osteoclasts or bone formation by osteoblasts. Yang et al (2011) showed that SDCP decreased bone turnover markers pertaining to both systems, with a significant decrease in the serum bone formation marker and inhibition of serum resorption markers. In this study, the bone resorption marker was significant lower for rats in the SDCP group at 16 weeks than for the other OVx rats, and the bone formation marker was also lower for rats in the SDCP group at 16 weeks than those in the OVx, ALN and CN groups.…”