Better Osteoporotic Fracture Healing with Sintered Dicalcium Pyrophosphate (SDCP) Treatment

Abstract

SummaryThe aim of this study was to evaluate the effect of sintered dicalcium pyrophosphate (SDCP) on fracture healing in an osteoporotic rat model. Female Sprague-Dawley rats (8 weeks old) were randomly allocated into five groups: sham-operated group, and bilateral ovariectomized group treated with SDCP, alendronate, calcitonin, or no treatment. Rats were sacrificed at 6 or 16 weeks after fracture. Fracture sites were examined by microcomputed tomography (microCT), histology, and mechanical testing. The results showed that SDCP mildly suppressed callus remodeling at 6 weeks, but not at 16 weeks. The lamellar bone in the callus area and new cortical shell formation in SDCP-treated group were similar to that of the sham group at 16 weeks after fracture, indicating there was no delayed callus remodeling into lamellar bone. At both 6 and 16 weeks after fracture, ultimate stress and elastic modulus were similar between the SDCP and sham groups, and the mechanical strength in these groups was better than that in other groups. Finally, analysis of the serum bone markers CTX-1 and P1NP suggested that SDCP decreased the bone turnover rate and promoted proper fracture healing. The effect of SDCP is superior to that of alendronate and calcitonin in the healing of osteoporotic fractures. (J Histochem Cytochem 62:565-576, 2014)

Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review

“…All of the 26 studies used the ovariectomy-induced osteoporosis model, and two of them used an additional low calcium diet [ 30 , 48 ]. A sham group was created in 14 studies [ 27 , 30 , 31 , 34 , 36 , 40 , 43 , 45 – 48 , 50 – 52 ]. One study used two different types of intramedullary nails in each osteoporotic fracture femur [ 44 ].…”

“…Eighteen studies had only one time point for the biomechanical test, and seven studies had two time points [ 6 , 31 , 33 , 41 , 42 , 44 , 46 ]. Only one study had four time points [ 49 ].…”

Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats

“… 16 , 18 OVX rats were divided into 2 groups, namely OVX group treated with isotonic sodium chloride solution as vehicle and OVX/SDCP group orally administered with 1 mL of 0.25 mg/mL (oral administration of 1.0 mg/kg/d) SDCP once a day (Purzer Pharmaceutical Co., Taipei, Taiwan). 13 , 15 Rats were treated 5 times/wk for 3 and 6 months post-OVX, respectively. Guideline for the Care and Use of Laboratory Animals issued by Council of Agriculture Executive Yuan, Taiwan, was used for maintaining and handling animals.…”

“…Sintered dicalcium pyrophosphate (SDCP) is a pyrophosphate analog which is biocompatible with bone in vivo and in vitro. 13 – 15 It has been shown to exert antiosteoporotic effects comparable to that of alendronate in ovariectomized rats though inducing osteoclast apoptosis. 13 Unlike bisphosphonates, SDCP has a high affinity for osteoblasts and induces osteoclast apoptosis by degradation of the Golgi apparatus in these cells.…”

“… 13 – 15 It has been shown to exert antiosteoporotic effects comparable to that of alendronate in ovariectomized rats though inducing osteoclast apoptosis. 13 Unlike bisphosphonates, SDCP has a high affinity for osteoblasts and induces osteoclast apoptosis by degradation of the Golgi apparatus in these cells. 16 Inflammation has been suggested to contribute to the severity of osteoporosis.…”