Sinonasal Teratocarcinosarcoma

Abstract

Sinonasal teratocarcinosarcoma (SNTCS) is a distinctly rare tumor characterized by a variegated histologic architecture of epithelial and mesenchymal components. By reported accounts, SNTCS is a highly malignant tumor displaying rapid, aggressive growth. Prognosis is poor: less than 45% of all patients survive past 5 years. Combination surgery and radiotherapy currently appear to be the most effective treatment. This report presents a 76-year-old African American man with a SNTCS in the right nasal cavity and paranasal sinuses. The patient was treated with combination surgical excision and postoperative radiation therapy. The clinical and pathologic features and clinical course will be discussed.

Intensity-modulated radiotherapy for sinonasal teratocarcinosarcoma

“…Radiological result reveals nonspecific features, depending on the location of the lesion. It usually shows opacification of one or several sinuses with bone destruction and positive enhancement [5,6,17] .…”

Epignatus of a Newborn: Postmortem Ct and Mri Imaging for Autopsy

“…Наиболее распространенным гистологическим типом в таких тератомах яв-лялся крупноклеточный рак [36]. К очень ред-ким формам относится и тератокарциносарко-ма полости носа и придаточных пазух [40,41]. Почти все такие опухоли выявлялись у взрослых мужчин и исходили из решетчатой пазухи и верхнечелюстной пазухи [42].…”

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

“…3,[9][10][11][12] These tumors arising in the sinonasal tract has an insidious course and becomes symptomatic only after invading surrounding tissues in advanced stages making the overall prognosis poor. 3 As the literature review about the tumor is limited and management protocols are not defined a multimodality treatment including surgery, radiation and chemotherapy appears an optimal approach.…”

“…3 Most of the literature reported a 89% incidence in males and 11% in females. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] The rapid growth and extensive local destruction hinders early diagnosis. Diagnosis is made by the presence of immature neural tissue and fetal epithelial structure admixed with various malignant and mesenchymal elements.…”

“…Diagnosis is made by the presence of immature neural tissue and fetal epithelial structure admixed with various malignant and mesenchymal elements. 3,[11][12][13][14][21][22][23][24] An origin from a primitive neural crest or stem or progenitor cell with multidirectional differentiation is currently favored. 14,20,24 Local recurrence after surgery was seen in 30 to 43%, hence, adjuvant treatment is recommended in the form of radiation and chemotherapy.…”