Sinonasal seromucinous hamartomas: Clinical features and diagnostic dilemma

Figures, Mindy R.; Nayak, Jayakar V.; Gable, Carl; Chiu, Alexander G.

doi:10.1016/j.otohns.2009.11.014

Cited by 12 publications

(11 citation statements)

References 4 publications

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“…To date, 19 cases of SH have been reported in the English language literature [12][13][14][15][16][17][18], exclusive of the two described here (Table 1). They typically arise on the posterior nasal septum or in the nasopharynx, although they have also been described on the lateral nasal wall and in the paranasal sinuses [15].…”

Section: Discussionmentioning

confidence: 89%

“…In the literature, only a single case with features of SH recurred, and interestingly, this lesion had hybrid features of both SH and REAH [13][14][15][16][17][18]. That patient underwent a simple re-excision and was well at last follow-up.…”

Section: Discussionmentioning

confidence: 92%

“…They all pursue a benign course with only rare reports of recurrence. SH, although first described in 1974 by Baillie and Batsakis [12], is really the newest of these entities, having only been more clearly described and characterized in the past several years [13][14][15]. Herein, we report two additional cases of SH that partly expand their histologic spectrum and review the typical histologic features, differential diagnosis, and literature pertaining to these interesting lesions.…”

Section: Introductionmentioning

confidence: 86%

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Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Khan

Chernock

Lewis

2011

Head and Neck Pathol

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The sinonasal tract is a complex anatomic site, home to a wide variety of reactive, inflammatory, benign, and malignant lesions. Inflammatory polyps and papillomas are usually easily recognized by pathologists. A poorly understood lesion that has been more clearly defined in recent years is the nasal hamartoma. The epithelial subtypes include seromucinous hamartoma, respiratory epithelial adenomatoid hamartoma, and hybrid lesions. Seromucinous hamartomas have only been recognized and substantially reported over the past few years. They are a diagnostic challenge, needing to be distinguished from low grade adenocarcinomas, and are of interest because most of the basic questions about their pathophysiology remain unanswered. Herein, we present two novel cases of seromucinous hamartoma with features that partly expand the morphologic spectrum of these lesions, discuss the differential diagnosis, and review the literature to compare our findings with previously reported cases with the aim of better understanding this interesting entity.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 86%

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Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Khan

Chernock

Lewis

2011

Head and Neck Pathol

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“…The entity was initially described by Baillie and Batsakis in 1974 [1] as a single case report. Since then, 20 additional cases have been reported in the English literature [2][3][4][5][6][7][8] (Table 1). The male to female ratio is approximately 1:1.…”

Section: Introductionmentioning

confidence: 99%

Sinonasal Seromucinous Hamartoma: A Review of the Literature and a Case Report with Focal Myoepithelial Cells

Fleming

Perez-Ordoñez

Nasser

et al. 2012

Head and Neck Pathol

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Seromucinous hamartoma is a benign lesion of the sinonasal tract. Since its description in 1974, only a small number of additional cases have been reported. It is composed of a proliferation of seromucinous glands and ducts within a variable fibrous stroma. The serous component typically stains positively for S100 (at least focally) and lacks p63 positive abluminal cells. The lack of myoepithelial/basal cells is an important diagnostic feature of seromucinous hamartoma; their absence could lead to an incorrect diagnosis of low-grade sinonasal adenocarcinoma. We report the case of a polypoid mass resected from the posterior nasal cavity and nasopharynx of a 54-year-old woman. The lesion contained a population of small and large glands lined by cuboidal to flattened cells within a hypocellular stroma varying from dense and sclerotic to myxoid. Additionally, there was a superficial focus of ciliated invaginated surface epithelium and glands. Throughout the lesion there were no cytologic or architectural features of malignancy. The histologic features were diagnostic of seromucinous hamartoma. Immunohistochemistry showed focal S100 positivity of the serous glands. However, in contrast to previously reported cases, the glands focally showed an outer basal layer that was calponin, p63 and actin positive. Our case demonstrates two important points. First, complete absence of p63 staining should not necessarily be a required feature in the diagnosis of seromucinous hamartoma. Second, the ciliated larger glands-in keeping with respiratory epithelial adenomatoid hamartoma (REAH)-support the suggestion that seromucinous hamartoma and REAH are a spectrum of lesions, often seen together.

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“…Seromucinous hamartoma is a rare benign glandular proliferation of the sinonasal tract and nasopharynx, which was first described by Baillie and Batsakis in 1974 as a single case report . Since then, 21 additional cases have been reported in the English literature (Table ) . These reports described a sinonasal or nasopharyngeal hamartoma consisting largely of seromucinous glands with a lobular arrangement embedded in a fibrous stroma.…”

Section: Introductionmentioning

confidence: 99%

Seromucinous hamartoma in the nasal cavity medial to the middle turbinate: Report of 2 cases and review of the literature

Lee

Huang

et al. 2014

Head & Neck

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Sinonasal seromucinous hamartomas: Clinical features and diagnostic dilemma

Cited by 12 publications

References 4 publications

Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Sinonasal Seromucinous Hamartoma: A Review of the Literature and a Case Report with Focal Myoepithelial Cells

Seromucinous hamartoma in the nasal cavity medial to the middle turbinate: Report of 2 cases and review of the literature

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