Seromucinous hamartoma in the nasal cavity medial to the middle turbinate: Report of 2 cases and review of the literature

Abstract

Seromucinous hamartoma of the nasal cavity is an exceedingly rare diagnosis but should be included in the differential diagnosis of a posterior nasal tumor. Most cases arise from the posterior nasal cavity medial to the middle turbinate rather than lateral to the middle turbinate.

Seromucinous hamartoma of inferior turbinate

“…Seromucinous hamartoma in the nasal cavity is a rare lesion. [ 1 – 4 ] The etiology of hamartoma is unknown, but chronic inflammation of the nasal mucosa associated with chronic rhinosinusitis, allergic rhinitis, or bronchial asthma is the most accepted hypothesis. [ 5 ] The lesion occurs predominantly in women, and the most common symptom is unilateral nasal obstruction, followed by nasal bleeding.…”

“…[ 5 ] The lesion occurs predominantly in women, and the most common symptom is unilateral nasal obstruction, followed by nasal bleeding. [ 1 – 4 ] The majority of these lesions occurred in either the posterior nasal cavity or the nasopharynx, and most have occurred from the posterior nasal cavity medial to the middle turbinate. [ 1 – 4 ] To our knowledge, this is the first case of seromucinous hamartoma to arise from the anterior nasal cavity.…”

“…[ 3 , 4 ] These lesions have similar clinical presentations and histopathologic and immunohistochemical features. [ 1 – 5 ] In addition, there are no criteria for definitive distinction between these lesions. [ 4 ]…”

“…Glandular neoplasia of the sinonasal tract is divided into benign tumors and malignant tumors. [ 1 – 4 ] Distinguishing between benign hamartoma and adenocarcinoma is important because benign tumors have rarely been reported to recur. [ 1 – 5 ] Seromucinous hamartoma is a rare benign glandular proliferation of the sinonasal tract and nasopharynx, and the majority of lesions occur on the posterior nasal septum.…”

“…[ 1 – 4 ] Distinguishing between benign hamartoma and adenocarcinoma is important because benign tumors have rarely been reported to recur. [ 1 – 5 ] Seromucinous hamartoma is a rare benign glandular proliferation of the sinonasal tract and nasopharynx, and the majority of lesions occur on the posterior nasal septum. [ 1 – 4 ] Herein, we report an unusual case of a patient with seromucinous hamartoma at the anterior end of the right inferior turbinate that was mistaken for low-grade, non-intestinal-type adenocarcinoma.…”