Sinonasal adenocarcinoma: Immunohistochemical marking and expression of oncoproteins

Bashir, Amani; Robinson, Robert A.; Benda, Jo Ann; Smith, Russell B.

doi:10.1002/hed.10285

Cited by 34 publications

(18 citation statements)

References 23 publications

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“…Notably, in larger studies, SNAIT and CRAIT showed similar histologic subtypes such as mucinous adenocarcinoma, signet ring carcinoma, and globlet cell carcinoma [2,5,10]. Although no principal differences between SNAIT and CRAIT exist, both tumors of our case showed varying differences of tubular differentiation, proliferation index, and the percentage of chromogranin and CK7-positive cells as previously reported [8,11]. Similar rates of positivity were observed for CDX2 and CK20 [3].…”

Section: Discussionsupporting

confidence: 87%

Synchronous adenocarcinomas of intestinal type of the inner nose and the colon

et al. 2007

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Section: Discussionsupporting

confidence: 87%

Synchronous adenocarcinomas of intestinal type of the inner nose and the colon

et al. 2007

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“…The most plausible hypothesis is an origin from a transformed duct epithelium [12][13][14][15][16][17]. Transformation of the non-neoplastic respiratory epithelium of the sinonasal tract to an intestinal phenotype, adjacent to adenocarcinoma, has been reported [7,[18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Rahimi

Akaev

Repanos

et al. 2016

Head and Neck Pathol

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Primary lingual intestinal-type adenocarcinomas are extremely rare with only a few cases described. A case with immunohistochemical expression of Androgen Receptor (AR) which was treated solely by chemo-radiotherapy is reported herein. A 54-year-old male was referred with symptoms of fullness in his tongue. Clinical examination showed an asymmetry of the tongue with a hard mass palpable within the middle of the tongue. Biopsy showed intestinal-type adenocarcinoma. The tumour showed positive staining with cytokeratin 7, cytokeratin 20, CDX2, AR, b-catenin and was mismatch repair proteins (MMR) proficient. The molecular analysis did not show mutations in the KRAS, NRAS, BRAF and PIK3CA genes. The patient was treated with radiochemotherapy and is in remission 3.5 years after the diagnosis. This is the first case of intestinal-type tongue adenocarcinoma which showed AR expression and was treated solely with radical chemoradiotherapy.

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“…23,26,27 In addition to mutations, p53 overexpression has been studied; the results obtained indicate that p53 accumulation is a common feature in adenocarcinoma, with immunopositivity ranging between 20 and 80%. 24,27,37 Overexpression of p53 in epithelial cells of ethmoidal mucosa was studied in biopsy samples from 60 woodworkers with a minimum of 10 years of occupational exposure to wood dust and no malignancy, in comparison to 50 nonexposed controls who underwent functional or esthetic nasal surgery, as well as in 15 cases of intestinal type adenocarcinoma. 38 The percentage of cells positive for p53 was significantly higher in wood-dust-exposed subjects in metaplastic epithelium (28.6 versus 7.9%; p < 0.001), in ciliated epithelium (11.7 versus 2.1%; p < 0.001) and in seromucous Cancer Genetics glands of the nasal stroma (12.5 versus 1.0%; p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Mutations in TP53 tumor suppressor gene in wood dust‐related sinonasal cancer

Holmila

Bornholdt

Heikkilä

et al. 2010

Intl Journal of Cancer

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The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and direct sequencing. A significant association between wood-dust exposure and adenocarcinoma histology was observed [adjusted odds ratio (OR) 12.6, 95% confidence interval (CI), 5.0-31.6]. TP53 mutations occurred in all histologies, with an overall frequency of 77%. TP53 mutation positive status was most common in adenocarcinoma (OR 2.0, 95% CI, 1.1-3.7; compared with squamous cell carcinoma), and mutation positivity showed an overall, nonsignificant association with wood-dust exposure (OR 1.6, 95% CI, 0.8-3.1). Risk of TP53 mutation was significantly increased in association with duration (!24 years, OR 5.1, 95% CI, 1.5-17.1), average level (>2 mg/m 3 ; OR 3.6, 95% CI, 1.2-10.8) and cumulative level (!30 mg/m 3 3 years; OR 3.5, 95% CI, 1.2-10.7) of wood-dust exposure; adjustment for formaldehyde affected the ORs only slightly. Smoking did not influence the occurrence of TP53 mutation; however, it was associated with multiple mutations (p 5 0.03). As far as we are aware, this is the first study to demonstrate a high prevalence of TP53 mutation-positive cases in a large collection of sinonasal cancers with data on occupational exposure. Our results indicate that mutational mechanisms, in particular TP53 mutations, are associated with work-related exposure to wood dust in sinonasal cancer.

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Sinonasal adenocarcinoma: Immunohistochemical marking and expression of oncoproteins

Abstract: Strong HER-2/neu staining in some cases suggests this oncogene may be involved in the genesis of SNA. Immunohistochemical staining with cytokeratin 7 may be potentially useful in differentiating primary from metastatic disease in sinonasal adenocarcinomas of the intestinal subtype.

Cited by 34 publications

References 23 publications

Synchronous adenocarcinomas of intestinal type of the inner nose and the colon

Synchronous adenocarcinomas of intestinal type of the inner nose and the colon

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Mutations in TP53 tumor suppressor gene in wood dust‐related sinonasal cancer

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