Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes

Choi, Hong Sang; Sturgis, Erich M.; Rashid, Asif; DeMonte, Franco; Luna, Mario A.; Batsakis, John G.; El‐Naggar, Adel K.

doi:10.1053/j.humpath.2003.08.024

Cited by 79 publications

(65 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition evidence that intestinal metaplasia of the sinonasal mucosa precede to the development of the enteric-type lends further credence to this hypothesis. 3 The lack of other genetic features typically reported in primary colonic adenocarcinoma in our enteric-type tumors, however, suggest that specific events related to their site of origin underlie these differences. We contend that subsequent genetic events, especially in the former, are most likely acquired during the progression as a result of locoregional and other epidemiological factors.…”

Section: Discussionmentioning

confidence: 77%

“…Our group has recently shown that the respiratory epithelium undergoes intestinal epithelial metaplasia ( Figure 2a) prior to the development of the enteric-form of sinonasal adenocarcinoma, supporting histogenetic resemblance to primary colonic carcinoma. 3 We, therefore, hypothesize that the enteric-type shares common genetic alterations with primary colonic adenocarcinoma and differs from the seromucinous-type.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

et al. 2005

View full text Add to dashboard Cite

Sinonasal adenocarcinomas, a relatively rare entity, are composed of distinctly different morphologic subtypes with variable biological behavior. To investigate the genetic events associated with their development and clinicopathologic features, we analyzed the alterations in K-ras, APC, b-catenin, hMLH1 and hMSH2 and p53 genes expression in a cohort of 15 primary tumors comprising the two main sinonasal adenocarcinoma subtypes (enteric and seromucinous). The patients consisted of 13 men and two women, who ranged in age from 50 to 87 years. Tumors were predominantly located in the ethmoid sinus. Eight tumors were Enteric-type, and seven were seromucinous type. Nine patients were smokers and four were nonsmokers; and no information was available on two patients. Two of the eight enteric-type, had K-ras mutation at codons 12A and 12B, and one showed microsatellite instability at BAT-25. Two patients with enteric-type tumors had a history of wood-dust exposure, and one had a K-ras mutation at 12A codon as well as p53 overexpression. No patients with the seromucinous type had any genetic abnormalities, except for overexpression of p53 in two tumors. Our results show that (1) a subset of enteric-type sinonasal adenocarcinoma shares certain genetic alterations with colonic adenocarcinomas, (2) the seromucinous-type sinonasal adenocarcinoma lacks alterations and may develop through a different pathway, (3) high p53 expression is associated with aggressive tumor features in both subtypes and (4) the enteric-type runs a more malignant course than the seromucinous counterpart.

show abstract

Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 99%

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The histogeneis of this rare histotype of the sinonasal tract is unclear. The most plausible hypothesis is an origin from a transformed duct epithelium [12][13][14][15][16][17]. Transformation of the non-neoplastic respiratory epithelium of the sinonasal tract to an intestinal phenotype, adjacent to adenocarcinoma, has been reported [7,[18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Rahimi

Akaev

Repanos

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

Primary lingual intestinal-type adenocarcinomas are extremely rare with only a few cases described. A case with immunohistochemical expression of Androgen Receptor (AR) which was treated solely by chemo-radiotherapy is reported herein. A 54-year-old male was referred with symptoms of fullness in his tongue. Clinical examination showed an asymmetry of the tongue with a hard mass palpable within the middle of the tongue. Biopsy showed intestinal-type adenocarcinoma. The tumour showed positive staining with cytokeratin 7, cytokeratin 20, CDX2, AR, b-catenin and was mismatch repair proteins (MMR) proficient. The molecular analysis did not show mutations in the KRAS, NRAS, BRAF and PIK3CA genes. The patient was treated with radiochemotherapy and is in remission 3.5 years after the diagnosis. This is the first case of intestinal-type tongue adenocarcinoma which showed AR expression and was treated solely with radical chemoradiotherapy.

show abstract

“…Non-itacs have been found to lack intestinal-specific markers and commonly demonstrate a respiratory-type profile (positive for ck7, and negative for ck20, cdx2, and villin). In contrast, itacs are usually consistent with an intestinal-type profile (negative for ck7, and positive for ck20, cdx2, and villin) 10 . Given the proximity of the sinonasal and nasopharyngeal regions, it is essential to differentiate between sinonasal adenocarcinomas and the similarappearing nasopharyngeal papillary adenocarcinomas.…”

Section: Discussionmentioning

confidence: 96%

Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature

et al. 2017

View full text Add to dashboard Cite

show abstract

Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes

Cited by 79 publications

References 36 publications

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature

Contact Info

Product

Resources

About