Singlet molecular oxygen generated by biological hydroperoxides

Miyamoto, Sayuri; Martinez, Gláucia Regina; Medeiros, Marisa H. G.; Mascio, Paolo Di

doi:10.1016/j.jphotobiol.2014.03.028

Cited by 120 publications

(105 citation statements)

References 98 publications

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“…This category of biochemical routes in terms of generation and biological significance of ROS have been reviewed elsewhere. 214, 323, 324 Taking 1 O 2 for example, which is the major cytotoxic species in eukaryotic cells, light-independent production of 1 O 2 during the cell life cycle would happen between i) H 2 O 2 and hypochlorite (ClO − ) during phagocytosis, ii) electron transfer reaction from excited carbonyl species, iii) superoxide anion reactions with organic or inorganic substances, iv) ozone reaction involving hydrotrioxide intermediates, v) peroxynitrite reactions with hydroperoxides or hydrogen peroxides, vi) decomposition of lipid hydroperoxides by reduction through Russell mechanism, and vii) enzymes (e.g., catalase, peroxidases) involved in metabolism, and so on. 323-325 The major routes and substances for 1 O 2 generation in biological systems are displayed in Fig.…”

Section: Non-photodynamic Approachesmentioning

confidence: 99%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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Section: Non-photodynamic Approachesmentioning

confidence: 99%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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“…The results of our experiments, based on EPR oximetry and time‐resolved detection of singlet oxygen phosphorescence at 1270 nm, did not indicate any measurable formation of singlet oxygen during photoactivation of this nanocrystalline material (data not shown). Nevertheless, it cannot be ruled out that in the system studied, singlet oxygen is formed via an alternative mechanism such as the Russell reaction, in which peroxyl radicals are involved . Production of 1 O 2 by Brp@TiO 2 upon its irradiation is also possible as a result of the interaction of superoxide anion with the dye oxidized form, that is bromopyrogallo red—Brp (Fig.…”

Section: Resultsmentioning

confidence: 99%

The Ability of Functionalized Fullerenes and Surface‐Modified TiO₂ Nanoparticles to Photosensitize Peroxidation of Lipids in Selected Model Systems

Kozińska

Łabuz

Broniec

et al. 2018

Photochem & Photobiology

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Photochemical properties of a new class of inorganic nanoparticles, namely a cationic C60 fullerene substituted with three quaternary pyrrolidinium groups (BB6) and a surface‐modified nanocrystalline TiO2 with bromopyrogallol red (Brp@TiO2) were examined for their effectiveness in photogenerating singlet oxygen and free radicals. In particular, their ability to photosensitize peroxidation of unsaturated lipids was analyzed in POPC:cholesterol liposomes and B16 mouse melanoma cells employing a range of spectroscopic and analytical methods. Because melanoma cells typically are pigmented, we examined the effect of melanin on the photosensitized peroxidation of lipids in liposomes and B16 melanoma cells, mediated by BB6 and Brp@TiO2 nanoparticles. The obtained results suggest that peroxidation of unsaturated lipids, photosensitized by BB6 occurs mainly, although not exclusively, via Type II mechanism involving singlet oxygen. On the other hand, if surface‐modified TiO2 is used as a photosensitizer, Type I mechanism of lipid peroxidation dominates, as indicated by the predominant formation of the free radical‐dependent cholesterol oxidation products. The protective effect of melanin was particularly evident when BB6 was used as a photosensitizer, suggesting that melanin could efficiently interfere with Type II processes.

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“…The decomposition of hydroperoxides is accountable for the generation of hydroxyl radicals [51]. In addition to this, these can infrequently be produced as a byproduct of immune action.…”

Section: Discussionmentioning

confidence: 99%

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

Mamun¹,

Khanum²,

Begum³

et al. 2016

J Coast Life Med

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Singlet molecular oxygen generated by biological hydroperoxides

Cited by 120 publications

References 98 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

The Ability of Functionalized Fullerenes and Surface‐Modified TiO₂ Nanoparticles to Photosensitize Peroxidation of Lipids in Selected Model Systems

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

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Singlet molecular oxygen generated by biological hydroperoxides

Cited by 120 publications

References 98 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

The Ability of Functionalized Fullerenes and Surface‐Modified TiO2 Nanoparticles to Photosensitize Peroxidation of Lipids in Selected Model Systems

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

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The Ability of Functionalized Fullerenes and Surface‐Modified TiO₂ Nanoparticles to Photosensitize Peroxidation of Lipids in Selected Model Systems