Single ultrasmall Mn2+-doped NaNdF4 nanocrystals as multimodal nanoprobes for magnetic resonance and second near-infrared fluorescence imaging

Wang, Xin; Hu, Huishan; Zhang, Hailu; Li, Chunyan; An, Bao-Li; Dai, Jianwu

doi:10.1007/s12274-017-1727-8

Cited by 47 publications

(35 citation statements)

References 40 publications

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“…From the nanomaterial design perspective, biocompatible inorganic NIR‐II emissive contrast agents have also found their usage in pharmaceutical research and development to leverage on the diagnostic function. [28f,31–32] Great efforts have been devoted to developing theranostic nanoplatforms, which can assist clinicians in real‐time visualization of therapeutic effect. Therefore, in addition to developing NIR‐II emissive inorganic nanomaterials with a simple targeting function, other therapeutic and imaging modalities have been integrated into a single nanoformulation.…”

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

“…Therefore, in addition to developing NIR‐II emissive inorganic nanomaterials with a simple targeting function, other therapeutic and imaging modalities have been integrated into a single nanoformulation. [28f,31,32b] Ag 2 S quantum dots have been reported to function as a potential theranostic nanoplatform. By a single component, Ag 2 S displays NIR‐II fluorescence and photothermal characteristics, which has been used for image‐guided tumor therapy (Figure b).…”

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

“…[28f] When Ag 2 S quantum dots were coupled with platinum (Pt) decorated gold nanorods, the multifunctional nanocomposites showed NIR‐II/Computed Tomography/PA (NIR‐II/CT/PA) trimodal imaging with photothermal therapeutic effect. [32b] Taking advantage of NIR‐II fluorescence imaging, this nanoassembly has also been applied for the quantitative detection of microRNAs in living cells with excellent sensitivity and selectivity. [32b] In addition, tri‐modal imaging has been reported with Mn 2+ ‐doped rare‐earth sodium neodymium fluoride (NaNdF 4 ) nanocrystals with a hydrodynamic diameter of 14 nm, where magnetic resonance imaging/NIR‐II/CT (MRI/NIR‐II/CT) imaging techniques are integrated simply using a single type of nanomaterial and utilized for high‐performance imaging of human mesenchymal stem cells.…”

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

“…[32b] In addition, tri‐modal imaging has been reported with Mn 2+ ‐doped rare‐earth sodium neodymium fluoride (NaNdF 4 ) nanocrystals with a hydrodynamic diameter of 14 nm, where magnetic resonance imaging/NIR‐II/CT (MRI/NIR‐II/CT) imaging techniques are integrated simply using a single type of nanomaterial and utilized for high‐performance imaging of human mesenchymal stem cells. [32a]…”

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

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Recent Advances of Optical Imaging in the Second Near‐Infrared Window

2018

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The near-infrared window between 1000 and 1700 nm, commonly termed the "second near-infrared (NIR-II) window," has quickly emerged as a highly attractive optical region for biological imaging. In contrast to conventional imaging in the visible region between 400 and 700 nm, as well as in the first NIR (NIR-I) window between 700 and 900 nm, NIR-II biological imaging offers numerous merits, including higher spatial resolution, deeper penetration depth, and lower optical absorption and scattering from biological substrates with minimal tissue autofluorescence. Noninvasive imaging techniques, specifically NIR-II fluorescence and photoacoustic (PA) imaging, have embodied the attractiveness of NIR-II optical imaging, with several NIR-II contrast agents demonstrating superior performance to the clinically approved NIR-I agents. Consequently, NIR-II biological imaging has been increasingly explored due to its tremendous potential for preclinical studies and clinical utility. Herein, the progress of optical imaging in the NIR-II window is reported. Starting with highlighting the importance of biological imaging in the NIR-II spectral region, the emergence and latest development of various NIR-II fluorescence and PA imaging probes and their applications are then discussed. Perspectives on the promises and challenges facing this nascent yet exciting field are then given.

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Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances of Optical Imaging in the Second Near‐Infrared Window

2018

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“…[93] Copyright 2018, Wiley-VCH. Based on the above results, a large number of rare earth-doped nanoprobes were synthesized for NIR II-emission bioimaging including CaF 2 :Y,Nd, [79] NaHoF 4 : Nd, [80] NaNdF 4 :Mn, [81] NaGdF 4 :Nd@NaYF 4 @NaGdF 4 :Nd,Yb,Er @NaYF 4 , [82] LaF 3 :Yb,Nd, [83] CaTiO 3 :Nd, [84] GdF 3 :Nd, [85] NaGdF 4 : Yb,Er,Nd@NaGdF 4 :Nd, [86] NaYF 4 :Nd@NaLuF 4 @SiO 2 @PS, [87] NaGdF 4 :Nd,Fe, [88] SrF 2 :Nd, [89] NaGdF 4 @NaGdF 4 :Yb,Er@NaYF 4 : Yb@NaNdF 4 :Yb, [90] and NaYbF 4 : Er,Ce@NaYF 4 . Reproduced under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License.…”

Section: Optimization Of Rare Earth-doped Nanoprobesmentioning

confidence: 99%

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

Liu

Jia

Zhou

2018

Advanced Therapeutics

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With the advantages of low biofluid scattering and minimal absorbance, light in a second near-infrared window (NIR II, 1000-1700 nm) either as a signal or as an excitation source is preferred for bioimaging and disease diagnosis, especially for cancer theranostics. Due to recent advances in chemical synthesis and imaging techniques, various NIR II probes have been evaluated for tumor luminescence image-guided cancer therapy and surgery. Furthermore, probes emitting optical, acoustic, or thermal signals under NIR II excitation have also been developed for upconversion luminescence, photoacoustic, and photothermal imaging of tumors. Herein, recent advances in the use of NIR II imaging probes in cancer theranostic applications are summarized along with future perspectives.

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

et al. 2019

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Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near‐infrared‐II (NIR‐II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR‐II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR‐II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR‐II bioimaging, advancements in the high‐performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR‐II imaging are discussed, summarizing the synthesis and chemical structures of NIR‐II dyes, chemical and optical properties of NIR‐II dyes, bioconjugation and biological behavior of NIR‐II dyes, whole body imaging with NIR‐II dyes for cancer detection and surgery, as well as NIR‐II fluorescence microscopy imaging. A key perspective on the direction of NIR‐II molecular dyes for cancer imaging and surgery is also discussed.

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Single ultrasmall Mn2+-doped NaNdF4 nanocrystals as multimodal nanoprobes for magnetic resonance and second near-infrared fluorescence imaging

Cited by 47 publications

References 40 publications

Recent Advances of Optical Imaging in the Second Near‐Infrared Window

Recent Advances of Optical Imaging in the Second Near‐Infrared Window

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

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