Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making

Mulert, Christoph; Seifert, Christian L.; Leicht, Gregor; Kirsch, V.; Ertl, Matthias; Karch, Susanne; Moosmann, Matthias; Lutz, Jürgen; Möller, Hans‐Jürgen; Hegerl, Ulrich; Pogarell, Oliver; Jäger, L.

doi:10.1016/j.neuroimage.2008.04.236

Cited by 132 publications

(92 citation statements)

References 48 publications

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“…The significance threshold was set to t Ն 2.95 ( p Ͻ 0.005, uncorrected for multiple comparisons, cluster size threshold of 10 voxels). This relatively liberal threshold is comparable with previous studies (Debener et al, 2005, Eichele et al, 2005Mulert et al, 2008) and ensures a low likelihood of false negatives (Goldman et al, 2009).…”

Section: Methodssupporting

confidence: 87%

Effects of Parametrical and Trial-to-Trial Variation in Prior Probability Processing Revealed by Simultaneous Electroencephalogram/Functional Magnetic Resonance Imaging

Scheibe¹,

Ullsperger²,

Sommer³

et al. 2010

J. Neurosci.

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Prior knowledge of the probabilities concerning decision alternatives facilitates the selection of more likely alternatives to the disadvantage of others. The neural basis of prior probability (PP) integration into the decision-making process and associated preparatory processes is, however, still essentially unknown. Furthermore, trial-to-trial fluctuations in PP processing have not been considered thus far. In a previous study, we found that the amplitude of the contingent negative variation (CNV) in a precueing task is sensitive to PP information (Scheibe et al., 2009). We investigated brain regions with a parametric relationship between neural activity and PP and those regions involved in PP processing on a trial-to-trial basis in simultaneously recorded electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) data. Conventional fMRI analysis focusing on the information content of the probability precue revealed increasing activation of the posterior medial frontal cortex with increasing PP, supporting its putative role in updating action values. EEG-informed fMRI analysis relating single-trial CNV amplitudes to the hemodynamic signal addressed trial-to-trial fluctuations in PP processing. We identified a set of regions mainly consisting of frontal, parietal, and striatal regions that represents unspecific response preparation on a trial-to-trial basis. A subset of these regions, namely, the dorsolateral prefrontal cortex, the inferior frontal gyrus, and the inferior parietal lobule, showed activations that exclusively represented the contributions of PP to the trial-to-trial fluctuations of the CNV.

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Section: Methodssupporting

confidence: 87%

Effects of Parametrical and Trial-to-Trial Variation in Prior Probability Processing Revealed by Simultaneous Electroencephalogram/Functional Magnetic Resonance Imaging

Scheibe¹,

Ullsperger²,

Sommer³

et al. 2010

J. Neurosci.

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“…Simultaneous stimulation and recording allows one a quantitative assessment of the startle response and the corresponding BOLD response in analogy to EEG/fMRI-data analysis on a single trial level [Esposito et al, 2009, in press;Mulert et al, 2008]. The single trial results of the individual startle measurement enter the statistical analysis of the event-related fMRI data and add valuable information which is otherwise lost.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiology meets fMRI: Neural correlates of the startle reflex assessed by simultaneous EMG–fMRI data acquisition

Neuner¹,

Stöcker²,

Kellermann³

et al. 2010

Human Brain Mapping

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The startle reflex provides a unique tool for the investigation of sensorimotor gating and information processing. Simultaneous EMG-fMRI acquisition (i.e., online stimulation and recording in the MR environment) allows for the quantitative assessment of the neuronal correlates of the startle reflex and its modulations on a single trial level. This serves as the backbone for a startle response informed fMRI analysis, which is fed by data acquired in the same brain at the same time. We here present the first MR study using a single trial approach with simultaneous acquired EMG and fMRI data on the human startle response in 15 healthy young men. It investigates the neural correlates for isolated air puff startle pulses (PA), prepulse-pulse inhibition (PPI), and prepulse facilitation (PPF). We identified a common core network engaged by all three conditions (PA, PPI, and PPF), consisting of bilateral primary and secondary somatosensory cortices, right insula, right thalamus, right temporal pole, middle cingulate cortex, and cerebellum. The cerebellar vermis exhibits distinct activation patterns between the startle modifications. It is differentially activated with the highest amplitude for PPF, a lower activation for PA, and lowest for PPI. The orbital frontal cortex exhibits a differential activation pattern, not for the type of startle response but for the amplitude modification. For pulse alone it is close to zero; for PPI it is activated. This is in contrast to PPF where it shows deactivation. In addition, the thalamus, the cerebellum, and the anterior cingulate cortex add to the modulation of the startle reflex.

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“…34,35 Effortful decisions depending on working memory and those that involve reasoning cause recruitment of the DLPFC 2,21,41 and the anterior cingulate cortex. 37,42,43 Decisions requiring cross-reference to the decision maker's value system, incorporation of long-term or contextual information and decisions made under uncertainty are known to burden the DLPFC. 20,38,[45][46][47] Finally, goal-directed DM specifically involves the anterior cingulate cortex during highly ambiguous situations in which the decision maker perceives several conflicting options and a high likelihood of error, 37,38 which also may explain the relative PFC redundancy among novices during primed intraoperative DM.…”

Section: Discussionmentioning

confidence: 99%

“Contemplating the Next Maneuver”

et al. 2017

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Objective: To investigate differences in the quality, confidence, and consistency of intraoperative surgical decision making (DM) and decision systems that operators use using functional neuroimaging AQ4. Summary Background Data: Novices are hypothesized to use conscious analysis (effortful DM) leading to activation across the dorsolateral prefrontal cortex, whereas experts are expected to use unconscious automation (habitual DM) in which decisions are recognition-primed and prefrontal cortex independent. Methods: A total of 22 subjects (10 medical student novices, 7 residents, and 5 attendings) reviewed simulated laparoscopic cholecystectomy videos, determined the next safest operative maneuver upon video termination (10 s), and reported decision confidence. Video paradigms either declared (''primed'') or withheld (''unprimed'') the next operative maneuver. Simultaneously, changes in cortical oxygenated hemoglobin and deoxygenated hemoglobin inferring prefrontal activation were recorded using Optical Topography. Decision confidence, consistency (primed vs unprimed), and quality (script concordance) were assessed. Results: Attendings and residents were significantly more certain (P < 0.001), and decision quality was superior (script concordance: attendings ¼ 90%, residents ¼ 78.3%, and novices ¼ 53.3%). Decision consistency was significantly superior in experts (P < 0.001) and residents (P < 0.05) than novices (P ¼ 0.183). During unprimed DM, novices showed significant activation of the dorsolateral prefrontal cortex, whereas this activation pattern was not observed among residents and attendings. During primed DM, significant activation was not observed in any group. Conclusions: Expert DM is characterized by improved quality, consistency, and confidence. The findings imply attendings use a habitual decision system, whereas novices use an effortful approach under uncertainty. In the presence of operative cues (primes), novices disengage the prefrontal cortex and seem to accept the observed operative decision as correct.

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Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making

Cited by 132 publications

References 48 publications

Effects of Parametrical and Trial-to-Trial Variation in Prior Probability Processing Revealed by Simultaneous Electroencephalogram/Functional Magnetic Resonance Imaging

Effects of Parametrical and Trial-to-Trial Variation in Prior Probability Processing Revealed by Simultaneous Electroencephalogram/Functional Magnetic Resonance Imaging

Electrophysiology meets fMRI: Neural correlates of the startle reflex assessed by simultaneous EMG–fMRI data acquisition

“Contemplating the Next Maneuver”

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