Single Transverse Apparent Leukonychia Caused by 5-Fluorouracil plus Leucovorin

Chen, Guan-Yu; Chen, WenChieh; Huang, Wen-Tsung

doi:10.1159/000070954

Cited by 13 publications

(6 citation statements)

References 2 publications

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“…It may be helpful to distinguish between some of the features of Mees’ lines and Muehrcke's lines. Muehrcke's lines disappear with pressure, while Mees’ lines do not; nail bed alternations in Muehrcke's lines usually change quickly in contradistinction to nail plate alternations in Mees’ lines, which usually persist until the nail grows out; and nail bed signs remain fixed while nail plate changes progress with nail growth 15 …”

Section: Discussionmentioning

confidence: 97%

Nail changes associated with chemotherapy in children

Chen

et al. 2006

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 97%

Nail changes associated with chemotherapy in children

Chen

et al. 2006

Acad Dermatol Venereol

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“…Total damage of the matrix epithelium (epidermolysis) may lead to development of a haemorrhagic blister under the nail plate and cause painful shedding of the nail plate (onychomadesis). The phenomenon is especially common during the treatment with docetaxel [12][13][14]. A so-called PATEO (periarticular thenar erythema with onycholysis) syndrome was recognized; it is characterized by onycholysis with concurrent erythematous lesions on the dorsal side of the hand, and areas of the Achilles tendon as well as ankle joints caused by the treatment with taxanes [15] (fig.…”

Section: Onycholysismentioning

confidence: 99%

“…Całkowite uszkodzenie nabłonka macierzy paznokcia (epidermoliza) może prowadzić do powstania krwotocznego pęcherza zlokalizowanego pod płytką paznokciową i powodować bolesne złuszczenie płytki (onychomadesis). Zjawisko to jest szczególnie często obserwowane podczas leczenia docetakselem [12][13][14]. Wyróżnia się tzw.…”

Section: Linie Beauunclassified

Periungual lesions secondary to chemotherapy with docetaxel

Sigorski¹,

Markiewicz²,

Owczarczyk‐Saczonek³

et al. 2019

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Chemotherapy is a basic treatment method of neoplasms at a systemic stage. Chemotherapy regimens including docetaxel are commonly used in every day clinical practice. Docetaxel is a chemotherapeutic agent that causes skin toxicity among other side effects. It involves alopecia and periungual lesions. The latter may cause pain as well as discomfort, and constitute a cosmetic problem. Sometimes they may lead to termination of the therapy due to negative effects on the quality of life and everyday activities. The aim of the article is to present clinical problems of patients undergoing chemotherapy with docetaxel that experience periungual lesions, and show treatment methods from a dermatologist's perspective. Moreover, prophylactic methods that prevent appearance of severe lesions are presented. StReSZcZenieChemioterapia jest podstawową metodą leczenia nowotworów w stadium uogólnienia. Schematy chemioterapii zawierające docetaksel są powszechnie stosowane w codziennej praktyce klinicznej. Docetaksel jest chemioterapeutykiem, który oprócz innych objawów niepożądanych powoduje toksyczność skórną, m.in. łysienie oraz zmiany okołopaznokciowe. Zmiany okołopaznokciowe mogą wywoływać ból, dyskomfort oraz stanowić problem kosmetyczny. Czasami są przyczyną zakończenia terapii z powodu negatywnego wpływu na jakość życia i codzienne funkcjonowanie. Celem pracy jest przedstawienie problemów klinicznych pacjentów poddanych chemioterapii docetakselem, u których wystąpiły zmiany okołopaznokciowe, a także metod leczenia z punktu widzenia dermatologa. Autorzy zaproponowali również metody zapobiegania powstawaniu zmian o dużym nasileniu.

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“…8,14 Fluorouracil A number of different nail toxicities have been attributed to fluorouracil including diffuse hypermelanosis, transverse bands, onycholysis, paronychial inflammation and pain, thickening of the nail beds, and hyperpigmentation. 8,14 Chen et al 53 described a case of single transverse apparent leukonychia, with bands corresponding to the number and duration of cycles, following combination chemotherapy with fluorouracil and high-dose leucovorin.…”

Section: Doxorubicinmentioning

confidence: 99%

Nail Toxicity Induced by Cancer Chemotherapy

Gilbar

Hain

Peereboom

2009

J Oncol Pharm Pract

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Nail toxicity is a relatively uncommon adverse effect linked to a number of chemotherapeutic agents. Clinical presentation varies, depending on which nail structure is affected and the severity of the insult. Nail changes may involve all or some nails. Toxicity may be asymptomatic and limited to cosmetic concerns, however, more severe effects, involving pain and discomfort can occur. Taxanes and anthracyclines are the antineoplastic drug groups most commonly implicated. It is suggested that the administration schedule may influence the incidence of nail abnormalities, for example reported cases linked to the weekly administration of paclitaxel.Before instituting chemotherapy, patients should be educated regarding potential nail toxicities and strategies for prevention implemented. Management includes appropriate nail cutting, avoiding potential irritants, topical, or oral antimicrobials, and possibly cessation or dose reduction of the offending agent. Cryotherapy, through the application of frozen gloves or socks, has been beneficial in reducing docetaxel-induced nail toxicity and may be effective for other drugs.

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Single Transverse Apparent Leukonychia Caused by 5-Fluorouracil plus Leucovorin

Cited by 13 publications

References 2 publications

Nail changes associated with chemotherapy in children

Nail changes associated with chemotherapy in children

Periungual lesions secondary to chemotherapy with docetaxel

Nail Toxicity Induced by Cancer Chemotherapy

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