Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity

Karimi, Golgis; Jamaluddin, Rosita; Mohtarrudin, Norhafizah; Ahmad, Zaid; Khaza’ai, Huzwah; Parvaneh, Maria

doi:10.1016/j.numecd.2017.06.020

Cited by 35 publications

(21 citation statements)

References 25 publications

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“…Meanwhile, adiponectin, an adipose tissue-secreted endogenous insulin sensitizer, was significantly reduced in the HFD-fed mice, in line with the occurrence of insulin resistance, which has been reported in obese mice or humans [29,30]. The administration of T17, however, significantly alleviated insulin resistance and decreased the serum levels of TG, T-CHO and LDL-C in HFD-fed mice, which may be partly explained by the significant increase in adiponectin, assumedly due to the reduction in adipocyte size in accordance with previous studies [31]. Adiponectin is known to play an important role in regulating energy homeostasis, and the improvement in adiponectin as a result of T17 feeding may be linked to the regulation of lipid metabolism, leading to a balanced serum lipid profile [32].…”

Section: Discussionsupporting

confidence: 90%

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Liu

Zhao

et al. 2020

Nutrients

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Lactobacillus plantarum ZJUFT17 (T17) is a potential probiotic bacterium isolated from Chinese traditional sourdough. The purpose of this study was to investigate its weight-reducing effects in mice fed a high-fat diet (HFD) and further to elucidate possible mechanisms. Male C57BL/6J mice fed HFD were given T17 (2–4 × 108 cfu) intragastrically for 10 weeks. The results showed that the administration of T17 significantly suppressed HFD-induced body weight gain, alleviated HFD-induced increase in serum lipids and decreased energy intake. The serum levels of obesity-related metabolic signaling molecules, including insulin, adiponectin, lipopolysaccharide (LPS) and the cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α, were markedly improved. The 16S rRNA gene sequencing revealed that T17 administration dramatically modulated the gut microbiota, suppressing pathogenic and pro-inflammatory microbes and stimulating the microbes favoring anti-obesity. The weight-reducing efficacy of T17 may be explained by its ability to ameliorate systemic inflammation and insulin resistance mediated by gut microbiota. This study revealed that T17 could ameliorate obesity and the concomitant metabolic syndrome in mice and that the lactic acid bacteria in the sourdough ecosystem may also possess anti-obesity/weight-reducing properties.

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Section: Discussionsupporting

confidence: 90%

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Liu

Zhao

et al. 2020

Nutrients

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“…In vivo trials, the decrease of body weight and fat mass and other features associated with obesity such as insulin resistance, low-grade inflammation, steatosis, fatty acids metabolism and gut microbiota changes have been studied. Moreover, the probiotic supplementation has traditionally been performed for relatively long periods of time (between 3 and 18 weeks) (Neyrinck et al, 2016; Bagarolli et al, 2017; Karimi et al, 2017; Ray et al, 2018). Concerning B. animalis species, some recent studies performed in mice fed with a HFD for a long-term period of time have evidenced that the administration of some strains of this species contributed to reduce body fat content, attenuated glucose intolerance and ameliorated metabolic endotoxemia, and adipose and hepatic inflammation (Chen et al, 2012; Stenman et al, 2014; Caimari et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice

et al. 2019

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Obesity has been recognized by the World Health Organization as a global epidemic. The gut microbiota is considered as a factor involved in the regulation of numerous metabolic pathways by impacting several functions of the host. It has been suggested that probiotics can modulate host gene expression and metabolism, and thereby positively influence host adipose tissue development and obesity related-metabolic disorders. The aim of the present work was to evaluate the effect of an exopolysaccharide (EPS)-producing Bifidobacterium strain on host glucose and lipid metabolism and the gut microbial composition in a short-term diet-induced obesity (DIO) in mice. C57BL/6J male mice were randomly divided into three groups: a control group that received control standard diet, a group fed a high-fat diet (HF), and a group fed HF supplemented with Bifidobacterium animalis IPLA R1. Fasting serum insulin as well as triglycerides accumulation in the liver were significantly reduced in the group receiving B. animalis IPLA R1. The treatment with the EPS-producing B. animalis IPLA R1 tended to down-regulate the expression of host genes involved in the hepatic synthesis of fatty acids which was concomitant with an upregulation in the expression of genes related with fatty acid oxidation. B. animalis IPLA R1 not only promoted the increase of Bifidobacterium but also the levels of Bacteroides-Prevotella . Our data indicate that the EPS-producing Bifidobacterium IPLA R1 strain may have beneficial effects in metabolic disorders associated with obesity, by modulating the gut microbiota composition and promoting changes in lipids metabolism and glucose homeostasis.

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“…Furthermore, administration of B. longum alone or mixed with L. casei Shirota reduced weight and triglycerides in HFD rats. Surprisingly, B. longum alone was better at modulating leptin level, fat mass, adipocyte size, lipoprotein lipase and PPAR-γ expression, and increasing adiponectin [120]. A recent study showed that a mixture of B. lactis Bi1, B. breve Bbr8, and B. breve BL10 (B. mix) was the best at ameliorating obesity in HFD mice compared to administration of single strains of LGG, L acidophilus LA1/K8, or alternative mixtures like L. bulgaricus LB2 with S. termophilus Z57.…”

Section: Changes In Microbiota Compositionmentioning

confidence: 99%

Probiotics: How Effective Are They in the Fight against Obesity?

2019

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Obesity has been associated with structural and functional changes in the gut microbiota. The abundance in, and diversity of, certain bacteria may favor energy harvest and metabolic pathways leading to obesity. Therefore, gut microbiota has become a potential target that can be manipulated to obtain optimal health. Probiotics have been shown to influence the composition of the gut microbiota, improve gut integrity, and restore the microbial shifts characteristic of obesity. Based on physical and biochemical parameters, metabolic and inflammatory markers, and alterations in gut microbe diversity, animal studies revealed beneficial results in obese models whereas the results in humans are sparse and inconsistent. Thus, the purpose of this review is to present evidence from animal studies and human clinical trials demonstrating the effects of various probiotic strains and their potential efficacy in improving obesity and associated metabolic dysfunctions. Furthermore, the review discusses current gaps in our understanding of how probiotics modulate gut microflora to protect against obesity. Finally, we propose future studies and methodological approaches that may shed light on the challenges facing the scientific community in deciphering the host–bacteria interaction in obesity.

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Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity

Abstract: B. longum supplementation in obesity was more beneficial in metabolic profile changes than the mixture species.

Cited by 35 publications

References 25 publications

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice

Probiotics: How Effective Are They in the Fight against Obesity?

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