Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Zhang, Yan; Sun, Xinhong; Wang, Yibin; Yan, Chengnan; Liu, Yanjie; Li, Jia; Zhang, Dongya; Zheng, Meng; Chung, Roger S.; Shi, Bingyang

doi:10.1002/adma.202300777

Cited by 3 publications

(1 citation statement)

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“…Introducing GSH sensitive chemical groups or chemical bonds, such as disulfide bond, diselenium bond and dinitrophenyl ether into the vectors is an effective release strategy in drug delivery systems [14]. Due to the concentration difference of GSH inside and outside the cell, the drug delivery systems can maintain structural stability outside the cell and be destroyed at high GSH concentration inside the cell to release drugs or genes efficiently [18,19].…”

Section: Introductionmentioning

confidence: 99%

Construction of GSH-responsive polyethyleneimine-based delivery vector for effective gene transfection

Kou,

Wang,

Zhu

et al. 2024

Nanotechnology

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The rise of gene therapy has solved many diseases that cannot be effectively treated by conventional methods. Gene vectors is very important to protect and deliver the therapeutic genes to the target site. Polyethyleneimine (PEI) modified with mannitol could enhance the gene transfection efficiency reported by our group previously. In order to further control and improve the effective gene release to action site, disulfide bonds were introduced into mannitol-modified PEI to construct new non-viral gene vectors PeiSM. The degrees of mannitol linking with disulfide bonds were screened. Among them, moderate mannitol-modified polyethyleneimine with disulfide bonds (M-PeiSM) showed the best transfection efficiency, and significantly enhanced long-term systemic transgene expression for 72 hours in vivo even at a single dose administration, and could promote caveolae-mediated uptake through up-regulating the phosphorylation of caveolin-1 and increase the loaded gene release from the nanocomplexes in high GSH intracellular environment. This functionalized gene delivery system can be used as an potential and safe non-viral nanovector for further gene therapy.

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Section: Introductionmentioning

confidence: 99%

Construction of GSH-responsive polyethyleneimine-based delivery vector for effective gene transfection

Kou,

Wang,

Zhu

et al. 2024

Nanotechnology

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Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway

Liu,

Ren,

Zhang

et al. 2025

Biomaterials

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Effect of the size of nucleic acid delivery systems on their fate in cancer treatment

Ye,

Gong,

Chen

et al. 2024

Explor Drug Sci

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Nucleic acid therapeutics are emerging as a promising class of medicines, offering unique therapeutic options for cancer at the gene level. However, the druggability of nucleic acid therapeutics is fundamentally restricted by their low stability, poor membrane permeability, and low bioavailability, necessitating the use of delivery vectors. Various delivery vectors have been developed for nucleic acid therapeutics. The fate of established nucleic acid delivery systems (NADS) in vivo substantially affects the delivery efficiency and therapeutic efficacy. The physicochemical properties of NADS (such as size, charge, shape, etc) are crucial for the interaction of NADS with various biological barriers in the body, thereby determining the fate of NADS in the body. Nanoparticle (NP) size is an important parameter defining the blood circulation, distribution, tumor accumulation, and cellular uptake of NADS. This mini-review briefly introduces the various biological barriers of NADS in cancer treatment and focuses on the influence of the particle size of delivery vectors on the in vivo fate of NADS and their therapeutic efficacy, which provides new insights into the rational design of NADS.

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Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Cited by 3 publications

References 0 publications

Construction of GSH-responsive polyethyleneimine-based delivery vector for effective gene transfection

Construction of GSH-responsive polyethyleneimine-based delivery vector for effective gene transfection

Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway

Effect of the size of nucleic acid delivery systems on their fate in cancer treatment

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