Effect of the size of nucleic acid delivery systems on their fate in cancer treatment
Mengyun Ye,
Junni Gong,
Wang Chen
et al.
Abstract:Nucleic acid therapeutics are emerging as a promising class of medicines, offering unique therapeutic options for cancer at the gene level. However, the druggability of nucleic acid therapeutics is fundamentally restricted by their low stability, poor membrane permeability, and low bioavailability, necessitating the use of delivery vectors. Various delivery vectors have been developed for nucleic acid therapeutics. The fate of established nucleic acid delivery systems (NADS) in vivo substantially affects the d… Show more
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