Airing can be a solution to introduce extra ventilation in large single zone buildings, especially where there are large aggregations of people such as churches or atriums. In naturally ventilated domestic and ancient buildings, opening of a window or door can introduce extra fresh air and remove particles and other contaminants emitted from people and other sources such as lit candles in churches. However, the energy use might be an issue in cold climates, where airing might lead to waste of heated air, at the same time as indoor air temperatures can be uncomfortably low. In the present study, the energy loss and ventilation rate due to airing in a large single zone (church) building is investigated via IDA-ICE simulation on annual basis in cold weather conditions. The results can be used in order to prepare airing guidelines for large single zone buildings such as atriums, churches, industry halls and large sport halls. According to the results, one-hour of airing in the studied church building resulted in 40-50 % of exchanged room air and, if practiced once a week, an increase of around 1 % in heating energy.