Single-shot photoacoustic imaging with single-element transducer through a spatiotemporal encoder

Abstract

. Significance Current photoacoustic (PA) imaging modalities typically require either serial detection with a single-element transducer or parallel detections with an ultrasonic array, indicating a dilemma between system cost and imaging throughput. PA topography through ergodic relay (PATER) was recently developed to address this bottleneck. However, PATER requires object-specific calibration due to varied boundary condition and must be recalibrated through pointwise scanning for each object before measurements, which is time-consuming and severely limits practical application. Aim We aim to develop a new single-shot PA imaging technique that only requires a one-time calibration for imaging different objects using a single-element transducer. Approach We develop an imaging method, PA imaging through a spatiotemporal encoder (PAISE), to address the above issue. The spatial information is effectively coded into unique temporal features by the spatiotemporal encoder, which allows for compressive image reconstruction. An ultrasonic waveguide is proposed as a critical element to guide the PA waves from the object into the prism, which effectively accounts for the varied boundary condition of different objects. We further add irregular-shaped edges on the prism to introduce randomized internal reflections and further facilitate the scrambling of acoustic waves. Results The proposed technique is validated through comprehensive numerical simulations and experiments, and it is demonstrated that PAISE can successfully overcome the changed boundary condition and can image different samples given a single calibration. Conclusions The proposed PAISE technique is capable of single-shot widefield PA imaging with a single-element transducer and does not require sample-specific calibration, which successfully overcomes the major limitation of previous PATER technology.

Quantitative classification of melasma with photoacoustic microscopy: a pilot study

“…As a hybrid imaging technique, photoacoustic imaging (PAI) has shown great potential in clinical (preclinical) diagnosis. [12][13][14][15][16][17][18][19] In particular, photoacoustic microscopy (PAM) imaging modality enables label-free high-resolution quantitative imaging of the skin through high optical absorption in endogenous hemoglobin and melanin [20][21][22][23][24][25][26][27] and simultaneously reconstructs the three-dimensional (3D) morphological structure of melanin and blood vessels. [28][29][30] At present, PAM has been successfully applied in the clinical (preclinical) diagnosis of psoriasis, 31,32 port wine stain, 33,34 melanoma, 35,36 and other human skin diseases.…”