Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector

Zhang, Yide; Hu, Peng; Li, Lei; Cao, Rui; Khadria, Anjul; Maslov, Konstantin; Tong, Xin; Zeng, Yushun; Jiang, Laiming; Zhou, Qifa; Wang, Lihong V.

doi:10.1038/s41551-023-01149-4

Cited by 4 publications

(2 citation statements)

References 71 publications

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Section: Introductionmentioning

confidence: 99%

Review of the Applications of Micro/Nanorobots in Biomedicine

Zhang,

Tang,

Cao

et al. 2024

ACS Appl. Nano Mater.

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The advancement of precision medicine in modern biomedicine has been significantly propelled by the emergence of micro/nanorobots. The combination of micro/nanorobots and biomedicine offers unique advantages and holds attractive potential for applications. It effectively addresses the challenges encountered by traditional robots in areas such as driving, sensing, intelligence and other aspects, especially in the application of cancer and cardiovascular diseases, which is a hot field of interdisciplinary research in recent years. This review succinctly delineates and analyzes the recent advancements of micro/nanorobots. First, the research achievements of micro/nanorobots in recent years are systematically classified and introduced from four perspectives: manufacturing design, drive control, biomedical application and degradation. In particular, in-depth discussions were conducted regarding the challenges and potential solutions encountered in each stage. Second, based on the latest research results of micro/nanorobots in biomedical applications, the development direction of industrial applications and key technical aspects that need to be paid attention to are emphasized. Finally, we discuss the challenges and the potential research opportunities of the micro/nanorobots. In the future, it is expected that micro/nanorobots will become more sophisticated and capable of performing multiple medical functions and tasks. They will be implemented in vivo to assist medical doctors in diagnosing and treating diseases. This advancement shows significant potential for the field of medicine.

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Section: Introductionmentioning

confidence: 99%

Review of the Applications of Micro/Nanorobots in Biomedicine

Zhang,

Tang,

Cao

et al. 2024

ACS Appl. Nano Mater.

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“…33,34 In addition, acoustic waves experience significantly less scattering within soft tissues, leading to PACT offering substantially superior spatial resolution when compared with pure optical imaging methods in deep tissue. 35 Moreover, thanks to the light-matter interactions, PACT utilizes various molecular contrasts, [36][37][38][39][40][41][42][43][44] including endogenous contrasts, such as hemoglobin, melanin, deoxyribonucleic acid/ribonucleic acid, water, protein, and lipid, 27,37,[45][46][47][48][49][50][51][52] and exogenous contrast agents, such as fluorescent proteins, organic dyes, and nanoparticles. 36,38,40,[53][54][55][56] Understanding the fundamental principles and applications of PACT is crucial for unlocking its full potential, which paves the way for exploring diverse PACT acoustic detection geometries that play a pivotal role in acquiring high-quality images.…”

Section: Introductionmentioning

confidence: 99%

Challenges and advances in two-dimensional photoacoustic computed tomography: a review

Zhang,

Miao,

2024

J. Biomed. Opt.

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Photoacoustic computed tomography (PACT), a hybrid imaging modality combining optical excitation with acoustic detection, has rapidly emerged as a prominent biomedical imaging technique.Aim: We review the challenges and advances of PACT, including (1) limited view, (2) anisotropy resolution, (3) spatial aliasing, (4) acoustic heterogeneity (speed of sound mismatch), and (5) fluence correction of spectral unmixing.Approach: We performed a comprehensive literature review to summarize the key challenges in PACT toward practical applications and discuss various solutions.Results: There is a wide range of contributions from both industry and academic spaces. Various approaches, including emerging deep learning methods, are proposed to improve the performance of PACT further. Conclusions:We outline contemporary technologies aimed at tackling the challenges in PACT applications.

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A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging

Zhang,

Jin,

Deng

et al. 2024

Microsyst Nanoeng

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Wearable ultrasound imaging technology has become an emerging modality for the continuous monitoring of deep-tissue physiology, providing crucial health and disease information. Fast volumetric imaging that can provide a full spatiotemporal view of intrinsic 3D targets is desirable for interpreting internal organ dynamics. However, existing 1D ultrasound transducer arrays provide 2D images, making it challenging to overcome the trade-off between the temporal resolution and volumetric coverage. In addition, the high driving voltage limits their implementation in wearable settings. With the use of microelectromechanical system (MEMS) technology, we report an ultrasonic phased-array transducer, i.e., a 2D piezoelectric micromachined ultrasound transducer (pMUT) array, which is driven by a low voltage and is chip-compatible for fast 3D volumetric imaging. By grouping multiple pMUT cells into one single drive channel/element, we propose an innovative cell–element–array design and operation of a pMUT array that can be used to quantitatively characterize the key coupling effects between each pMUT cell, allowing 3D imaging with 5-V actuation. The pMUT array demonstrates fast volumetric imaging covering a range of 40 mm × 40 mm × 70 mm in wire phantom and vascular phantom experiments, achieving a high temporal frame rate of 11 kHz. The proposed solution offers a full volumetric view of deep-tissue disorders in a fast manner, paving the way for long-term wearable imaging technology for various organs in deep tissues.

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Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector

Cited by 4 publications

References 71 publications

Review of the Applications of Micro/Nanorobots in Biomedicine

Review of the Applications of Micro/Nanorobots in Biomedicine

Challenges and advances in two-dimensional photoacoustic computed tomography: a review

A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging

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