2017
DOI: 10.1590/0074-02760170347
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Single shot of 17D vaccine may not confer life-long protection against yellow fever

Abstract: The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus . Until 2013, the World Health Organization (WHO) recommended the administration of a vaccine dose every ten years. A new recommendation of a single vaccine dose to confer life-long protection against YFV infection has since been established. Recent evidence published elsewhere … Show more

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Cited by 16 publications
(11 citation statements)
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References 8 publications
(10 reference statements)
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“…Although these studies generally support sustained immunity following YF vaccine, there have been concerns noted about whether a single dose of YF vaccine is adequate. [31][32][33][34][35] However, if the current studies are taken together, the overall long-term neutralizing antibody rate is 85% (238/280), which is comparable to the proportion we report here.…”
Section: Discussionsupporting
confidence: 77%
“…Although these studies generally support sustained immunity following YF vaccine, there have been concerns noted about whether a single dose of YF vaccine is adequate. [31][32][33][34][35] However, if the current studies are taken together, the overall long-term neutralizing antibody rate is 85% (238/280), which is comparable to the proportion we report here.…”
Section: Discussionsupporting
confidence: 77%
“…Since 2013, WHO has recommended a single dose of yellow fever vaccine for life-long immunity, and the amended International Health Regulations (2005) no longer require revaccination every 10 years 5, 16. Although it followed evidence of long-term immunogenicity,17, 18 this policy change has been controversial 19, 20, 21, 22. The one-dose recommendation bypasses the question of the duration of protective immunity elicited in infants, the target population of immunisation programmes in endemic countries 6 .…”
Section: Discussionmentioning
confidence: 99%
“…The revision to life-long protection was partly based on the paucity of identified vaccine failures in vaccinated individuals, although post-marketing monitoring for break-through infections is lacking. Since the presence of YF neutralizing antibodies is associated with protection, this recommendation has caused debate about whether a single dose of YF vaccine can protect travelers whose neutralizing antibodies have declined and who are traveling to a high-risk area [50][51][52][53][54][55].…”
Section: Duration Of Protectionmentioning
confidence: 99%