2020
DOI: 10.1186/s40794-020-0101-0
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Yellow fever control: current epidemiology and vaccination strategies

Abstract: Yellow fever (YF) outbreaks continue, have expanded into new areas and threaten large populations in South America and Africa. Predicting where epidemics might occur must take into account local mosquito populations and specific YF virus strain, as well as ecoclimatic conditions, sociopolitical and demographic factors including population size, density, and mobility, and vaccine coverage. Populations of Aedes aegypti and Aedes albopictus from different regions vary in susceptibility to and capacity to transmit… Show more

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Cited by 78 publications
(70 citation statements)
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References 79 publications
(99 reference statements)
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“…YFV is also transmitted by Aedes aegypti mosquitoes and was first isolated from the blood of a patient in Ghana in 1927, and an effective vaccine (17D strain) was subsequently made available in 1937 [7]. Despite this, YFV infections have remained a threat to global health, with outbreaks expanding into new areas that put large populations in South America and Africa at risk [1,132]. YFV is currently endemic in over 45 countries globally and causing around 200,000 severe cases and up to 60,000 deaths every year according to a WHO estimation [132].…”
Section: Yellow Fever Virusmentioning
confidence: 99%
“…YFV is also transmitted by Aedes aegypti mosquitoes and was first isolated from the blood of a patient in Ghana in 1927, and an effective vaccine (17D strain) was subsequently made available in 1937 [7]. Despite this, YFV infections have remained a threat to global health, with outbreaks expanding into new areas that put large populations in South America and Africa at risk [1,132]. YFV is currently endemic in over 45 countries globally and causing around 200,000 severe cases and up to 60,000 deaths every year according to a WHO estimation [132].…”
Section: Yellow Fever Virusmentioning
confidence: 99%
“…Yellow fever (YF) is a potentially fatal mosquito-borne disease caused by the neurovirulent and viscerotropic YF virus (YFV), from the genus flavivirus, family Flaviviridae . The mainstay of YF control involves control of the mosquito vectors Aedes Albopictus and Aedes aegypti , and vaccination [ 1 ]. The attenuated YF vaccine was developed in 1937 by Theiler and Smith through serial passages of the YFV wild-type Asibi strain in mice and chick minced embryo culture, generating the non-neurovirulent strain 17D which protected monkeys from challenge with a virulent strain of the virus with production of neutralizing antibodies [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
“…Large outbreaks have occurred in recent years in Angola, Democratic Republic of Congo and Brazil [ 2 ]. A revised strategy to Eliminate Yellow Fever Epidemics (EYE) was launched by the World Health Organization (WHO) in 2017, with affordable vaccines and a sustained vaccine market representing key objectives [ 3 , 4 ]. Yellow fever (YF) is prevented by an effective live attenuated vaccine (17D), with a single dose able to confer life-long protection in most people.…”
Section: Introductionmentioning
confidence: 99%