Single photon emission computed tomography with iodoamphetamine-123 and neuropsychological studies in long-term abstinent alcoholics

Dupont, Renee M.; Rourke, Sean B.; Grant, Igor; Lehr, Patricia P.; Reed, Robert J.; Challakere, Kedar; Lamoureux, Guy; Halpern, Samuel E.

doi:10.1016/0925-4927(96)02769-2

Cited by 25 publications

(18 citation statements)

References 55 publications

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“…In addition, there is conflicting evidence regarding the importance of variables such as duration and recency of alcohol use in individuals with a history of past alcohol abuse who are not acutely intoxicated. Some investigators have demonstrated only modest recovery while others reveal a more complete recovery of cognitive functioning and normalization of brain morphology in abstinent alcoholics with varying periods of abstinence (Brown et al, 2000;Dupont et al, 1996;Mann et al, 1995Mann et al, , 1999Selby and Azrin, 1998). Thus, while at first overview the cumulative hypothesis appears straightforward as it relates to greater anatomic and neurocognitive deficits in those who have a TBI while under the influence of alcohol and also have a history of alcohol abuse, there are numerous factors that need to be considered.…”

Section: Cumulative Hypothesismentioning

confidence: 92%

“…Research has related other physiological abnormalities in the human brain exposed to chronic alcohol use including abnormal EEG activity (Ronty et al, 1993), reduced cerebral blood flow (Berglund et al, 1987;Caspari et al, 1993;Dally et al, 1988;Dupont et al, 1996;Hata et al, 1987;Volkow et al, 1994), cerebral metabolic alterations (Adams et al, 1993;Gilman et al, 1996;Volkow et al, 1990), alteration in white matter fiber coherence as measured by diffusion tensor imaging (Mann et al 2001), and changes in evoked potential measurements (Baguley et al, 1997). Consistent with the structural and physiological changes noted above, there is further evidence for cognitive dysfunction manifested in long-term alcoholics without TBI, where impairments in abstraction, visual scanning, perceptuomotor speed, verbal memory, and mental flexibility have been demonstrated (Di Scalafani et al, 1995;Emsley et al, 1997;Nixon, 1993, 1998;Parsons and Stevens, 1986;Wang et al, 1993).…”

Section: Cumulative Hypothesismentioning

confidence: 99%

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Alcohol Abuse and Traumatic Brain Injury: Quantitative Magnetic Resonance Imaging and Neuropsychological Outcome

Wilde

Bigler

Gandhi

et al. 2004

Journal of Neurotrauma

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Prior or concurrent alcohol use at the time of traumatic brain injury (TBI) was examined in terms of post-injury atrophic changes measured by quantitative analysis of magnetic resonance imaging (MRI) and neuropsychological outcome. Two groups of TBI subjects were examined: those with a clinically significant blood alcohol level (BAL) present at the time of injury (TBI + BAL) and those without a significant BAL (TBI-only). To explore the potential impact of both acute and chronic alcohol use, subjects in both groups were further clustered into one of four subgroups (NONE, MILD, MODERATE or HEAVY) based upon available information regarding their pre-injury alcohol use. One-way analysis of covariance (ANCOVA) and multiple analysis of covariance (MANCOVA) were used with subject grouping as the main factor. Age, injury severity as measured by Glasgow Coma Scale (GCS) score, years of education, total intracranial volume (TICV), and the number of days post-injury were included as covariates where appropriate. Increased general atrophy was observed in patients with (a) a positive BAL and/or (b) a history of moderate to heavy pre-injury alcohol use. In addition, performance on neuropsychological outcome variables (WAIS-R and WMS-R Index scores) was generally worse in the subgroups of patients with positive BAL and a history of preinjury alcohol use, as compared to the other TBI groups though not statistically significant. Implications of alcohol use, at the time of brain injury, are discussed.

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Section: Cumulative Hypothesismentioning

confidence: 92%

Section: Cumulative Hypothesismentioning

confidence: 99%

Alcohol Abuse and Traumatic Brain Injury: Quantitative Magnetic Resonance Imaging and Neuropsychological Outcome

Wilde

Bigler

Gandhi

et al. 2004

Journal of Neurotrauma

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“…Unfortunately, there is not a known reliable "normal" brain region in alcoholism to use as the reference region. Alternatively, it is possible that SPECT measures are independent of overt neurobehavioral measures (Dupont et al, 1996;Gansler et al, 1999). However, given the small sample size of the present investigation, particularly subgroup comparisons, the above interpretations are suggestive rather than confirmatory.…”

Section: Relationship Of Imaging and Neuropjychological Measures In Amentioning

confidence: 45%

Hypoperfusion of the Cerebellum and Aging Effects on Cerebral Cortex Blood Flow in Abstinent Alcoholics: A SPECT Study

Harris

Oscar‐Berman²,

Gansler³

et al. 1999

Alcoholism Clin & Exp Res

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“…Some studies have also reported that brain metabolism is increased during withdrawal period from alcohol [7,12]. There are also studies reporting that cerebral hypoperfusion improves in long-term abstinent alcoholics [13].…”

Section: Introductionmentioning

confidence: 99%

Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: a SPECT study

Erdoğan¹,

Vardar²,

Altun³

et al. 2018

Journal of Surgery and Medicine

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How to cite / Atıf için: Erdoğan E, Vardar E, Altun GD, Fırat MF. Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: SPECT study. J Surg Med. 2018;2(3):257-261. AbstractAim: Alcohol dependence has negative effects on the structure and functionality of the brain. The age of onset of alcohol is an important parameter in the grouping of alcoholics. The aim of this study is to compare whether regional cerebral blood flow (r-CBF) values differ between early (EO) versus late onset (LO) alcoholic patients. Methods: A total of 33 male patients with alcohol dependence as per DSM-IV criteria and 13 healthy controls were enrolled for the study. Regional measures of cortical cerebral blood flow were assessed using a high resolution Tc99m-HMPAO single photon emission computed tomography (SPECT). Alcoholic subjects were divided into two groups according to onset of problematic alcohol drinking age.Results: When three groups were compared, r-CBF differences were obtained in inferior frontal, inferior temporal, inferior left occipital and middle left frontal regions. Decreased r-CBF values were found in LO group when they compared to controls in both lower frontal and temporal regions (p<0.05). LO group showed significant reduced r-CBF values in regions of inferior frontal and temporal, inferior left occipital and middle left frontal when compared with EO. Conclusion: Our findings revealed that, there were differences in r-CBF values in EO and LO alcoholics at early abstinence period. These findings suggest that frontal lobes have a key role in alcoholism neurobiology, as noted in previous studies. Repeating the measurements after a long-term abstinence will be useful in revealing differences among the alcoholic groups.

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Single photon emission computed tomography with iodoamphetamine-123 and neuropsychological studies in long-term abstinent alcoholics

Cited by 25 publications

References 55 publications

Alcohol Abuse and Traumatic Brain Injury: Quantitative Magnetic Resonance Imaging and Neuropsychological Outcome

Alcohol Abuse and Traumatic Brain Injury: Quantitative Magnetic Resonance Imaging and Neuropsychological Outcome

Hypoperfusion of the Cerebellum and Aging Effects on Cerebral Cortex Blood Flow in Abstinent Alcoholics: A SPECT Study

Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: a SPECT study

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