Single nucleotide variants in the β2-adrenergic and β3-adrenergic receptor genes explained 18.3% of adolescent obesity variation

Abstract

Associations of obesity with its candidate genes, b-adrenergic receptor genes (ADRBs), peroxisome proliferator-activated receptor-c (PPARc), and uncoupling proteins (UCPs) were studied in Korean adolescents. We analyzed the obesity-related phenotypes body mass index (BMI), percentage of body fat, plasma leptin and insulin levels, fasting glucose concentration, and plasma lipid profile in 329 teenagers to investigate the effects of seven single nucleotide variants 252G/A, 523C/ A and 1053G/C in ADRB2; Trp64Arg in ADRB3; 161C/ T in PPARc; Ala55Val in UCP2; and 210C/T in UCP3. The 1053G/C polymorphism (P < 0.05) in the ADRB2 gene and the Trp64Arg polymorphism (P < 0.01) in the ADRB3 gene were associated with BMI after adjustment for dietary energy intake. Trp64Arg polymorphism also influenced percentage of body fat (P < 0.01) and plasma leptin level (P < 0.05). Furthermore, significant interaction effects between the 1053G/C and Trp64Arg polymorphisms were observed on BMI (P < 0.01). The polymorphisms of the ADRB2 and ADRB3 genes explained 4.3% and 10.1% of the variation on BMI, and the two loci effect, including their epistasis, explained 18.3%. We concluded that 1053G/C and Trp64Arg polymorphisms of the ADRB genes additively and interactively contributed to the variation of complex adolescent obesity.

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

“…In humans, the beta-3 adrenergic receptor is predominantly expressed in visceral adipose tissue (Krief et al, 1993). Notably, the Arg allele of this SNP has been linked with increased BMI, adiposity and obesity in children (Arashiro et al, 2003;Endo et al, 2000;Erhardt et al, 2005;Ochoa et al, 2004;Park et al, 2005) supporting the evidence in adults Pierola et al, 2007), and the increased risk for obesity at this ADRB3 loci may be driven partly by an interaction effect of the PPARG SNP Pro12Ala Hsueh et al, 2001;Ochoa et al, 2004). Other studies in young children between the ages 4-10 years and in adolescents report no signifi cant effects of Trp64Arg variants on BMI, weight or height when this variant is examined in isolation (Cecil et al, 2007;Haworth et al, 2008a;Hinney et al, 1997;Kurokawa et al, 2003).…”

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

“…74 Genetic polymorphisms of ADRB3 (beta-3-adrenergic receptor), known for its involvement in lipolysis and thermogenesis in adipocytes, are associated with birthweight in animals and obesity in humans. 75,76 Impaired function of SLC2A3/ GLUT3 (solute carrier family 2A3/glucose transporter 3), which is involved in fetoplacental growth and metabolism, has been linked with intrauterine growth restriction and adiposity in animal models. [77][78][79] Although twin numbers are relatively small, the associations we found do support the hypothesis that epigenetic factors accumulated in utero can contribute to low birthweight and predisposition to complex diseases in later life.…”

What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?

“…The Glu27 variant has been shown to be associated with obesity, but not all of the results have been replicated unambiguously in all studies. [38][39][40] In the Park et al survey, 41 a group of adolescents was studied to determine the relationship between the ADRB2 gene polymorphism and obesity. This study included 329 unrelated children.…”