Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Cecil, Joanne E.; Dalton, Michelle; Finlayson, Graham; Blundell, John; Hetherington, Marion M.; Palmer, Colin N.A.

doi:10.3109/09540261.2012.685056

Cited by 49 publications

(48 citation statements)

References 150 publications

(175 reference statements)

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“…The FTO rs9939609 minor allele, the risk allele for obesity, increased the risk of type 2 diabetes, this association remaining statistically significant even after adjustment for BMI [9]. Similar results were reported in a Scandinavian population [10].…”

Section: Discussionsupporting

confidence: 75%

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Grzeszczak

Molsa

Tłuczykont

et al. 2017

Endokrynologia Polska

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Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people. Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40-60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay. Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old. Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).

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Section: Discussionsupporting

confidence: 75%

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Grzeszczak

Molsa

Tłuczykont

et al. 2017

Endokrynologia Polska

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“…This study included only women, Attaoua et al also studied only females and found, besides the association with obesity, a correlation of rs1421085 with insulin resistance. The relation of FTO with insulin resistance was also reported by Cecil 20,24 .…”

Section: Discussionmentioning

confidence: 81%

“…The most frequent FTO SNP would be rs9939609, as seen in studies relating BMI and body fat to the SNP children and adolescents. A small number of studies conducted in children measured the indirect intake of energy associated with the FTO and confirmed the higher risk of obesity due to reduced satiety, preference for energy dense food and not for energy expenditure as suggested by the literature 24 . …”

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confidence: 99%

The Role of Fat Mass and Obesity Associated Gene (Fto) in Satiety and Binge Eating Disorder

Castro¹,

Horvath²,

Kops³

et al. 2015

cbr

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Obesity is a major health problem and one of the biggest predictors of the development of chronic diseases. Variations in the Fat mass and obesity associated gene (FTO) have been shown to associate strongly with obesity. Among patients with severe obesity, there is a subpopulation that presents an eating disorder known as Binge Eating Disorder. Because of its expression in the hypothalamus, FTO could be associated with modulation of satiety and, perhaps, play a role in the genesis of BED, contributing to severe obesity. A search in PubMed was carried out with the following terms: Morbid Obesity AND FTO, FTO AND Satiety Response, Binge Eating Disorder AND FTO. No restriction on the date of publication, language or type of design was applied. Sixteen articles were found. Twelve were related to FTO and grade III obesity, and three were related to FTO and satiety. Ten studies were excluded. Thus, six articles were evaluated in this review. The scarce literature limits further conclusions about the potential impact of the associations with FTO in the treatment of obesity, but all articles included in this revision show association with at least one SNP of FTO. Further studies are required to clarify these associations, especially in relation to rs9939609 (A/T), because, up to this moment, it seems to be the one variant with greatest impact on obesity in humans. Keywords: Obesity; FTO; satietyObesity is one of the main health problems in the 21st Century. It is an established risk factor for conditions such as Type 2 diabetes mellitus, cardiovascular disease and cancer 1 .The prevalence of overweight and obesity has doubled in the last thirty years. In Brazil, a 2008/2009 survey of the Ministry of Health showed that 8.9% of the population is obese. In the South of the country, 10.1% of the male population and 15.1% of the female population is obese. Brazilian estimates point out that, in the year 2025, the country will have the fifth largest prevalence of obesity worldwide 2 . Clinically, obesity is diagnosed in the presence of a body mass index (BMI) equal to or higher than 30 kg/m 2 , in adults 3 .Recent studies show associations of BMI with body fat and with the the "Fat mass and obesity associated" (FTO) gene 4 , located in chromosome 16q12.2 5,6 . Variations in this gene (single-nucleotide polymorphisms -SNPs) were strongly associated with obesity and diabetes mellitus 7 . The association of FTO with human obesity has been shown in caucasian populations studies [8][9][10][11] . Besides the association with BMI and higher risk for overweight and obesity, SNPs in FTO have been associated with obesity and body weight 5,8,11 , leptin levels 11 , subcutaneous fat 5,8 , fat mass 5,8,11 and waist circumference 11 .The messenger RNA (mRNA) of FTO is expressed in the hypothalamus 12 , an area that is connected with appetite regulation; in rodents, FTO mRNA expression in the hypothalamus is modulated by acute food deprivation 13 . One recent study, in human adults, has found differences in the caloric intake, but...

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“…A genetic contribution to several aspects of eating behavior was evidenced by numerous studies [reviewed in [20,21,22]]. Twin studies, in particular, have revealed a strong heritability for various components of eating behavior in children including both appetitive traits, such as hunger, eating rate, and satiety responsiveness [23,24,25,26,27], and behavioral traits, including food preferences and neophobia [25,28].…”

Section: Introductionmentioning

confidence: 99%

A Common Genetic Variant in the Insulin Receptor Gene Is Associated with Eating Difficulties at 2 Years of Age in a Cohort of Preterm Infants

Amarger¹,

Bouvagnet²,

Moyon³

et al. 2015

Lifestyle Genomics

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Background/Aims: Children born preterm are more likely than full-term infants to develop eating difficulties that can affect their growth. Although this behavior is certainly influenced by their fetal and postnatal history, a large individual variability exists that results from a complex interaction between genetic and environmental factors. We performed an original pilot study to identify common genetic variants associated with eating difficulties at 2 years of age in the POLYNUCA cohort of preterm infants. Methods: Eating behavior was assessed using a parental questionnaire in a cohort of 234 very preterm infants (including 38 pairs of twins). Eighty-two common single nucleotide polymorphisms (SNPs) were selected in a total of 40 candidate genes involved in the regulation of energy homeostasis and food intake. Results: Eating behavior was strongly correlated in monozygotic (r = 0.92, p = 0.001) but not dizygotic twins (r = 0.27, p = 0.14), suggesting a strong heritability of this trait. One SNP (rs11671975) in the insulin receptor (INSR) gene was significantly associated with eating behavior. This effect was maintained after adjustment for birth weight Z score and maternal education level, two factors that are associated with eating difficulties at 2 years of age. Conclusion: The INSR gene is potentially associated with eating difficulties in preterm infants.

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Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Cited by 49 publications

References 150 publications

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

The Role of Fat Mass and Obesity Associated Gene (Fto) in Satiety and Binge Eating Disorder

A Common Genetic Variant in the Insulin Receptor Gene Is Associated with Eating Difficulties at 2 Years of Age in a Cohort of Preterm Infants

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