Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-β1 in Iranian children with atopic dermatitis

Abstract

We found a strong association between the polymorphisms of the TGF-β1 gene at codon 10 and codon 25 positions and atopic dermatitis.

Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis

“…The linkage disequilibrium between the IL-10 -819 T/C and − 592 C/A polymorphisms exists in some reports [15, 21]. However, different genotype frequencies were also reported in other reports [17, 18, 35, 37]. Here, we also pooled the available data to perform a meta-analysis, which did not strongly support the genetic relationship between the IL-10 -592 C/A SNP and the risk of atopic dermatitis.…”

“…In 2013, Chen, et al included seven case-control studies [17–19, 21, 32, 34, 35] to perform a meta-analysis of the association between the IL-10 -1082 A/G polymorphism and the risk of atopic dermatitis [23]. In the present study, we collected the available data from diverse sources and finally added another eight new case-control studies [15, 16, 20, 30, 31, 33, 36, 37] to conduct another updated meta-analysis under the genetic models of allele A vs. G, GG vs. AA, AG vs AA, AG + GG vs AA, GG vs AA+AG and carrier A vs. G. Subgroup analyses stratified by ethnicity, country and HWE were also conducted. Our data failed to support the strong genetic link between the IL-10 -1082 A/G SNP and the risk of atopic dermatitis, which is in line with the outcomes of the above meta-analyses.…”

“…Recently, another meta-analysis by Zhao, et al [39] reported the same result on the potential association between IL-10 -1082 A/G SNP and atopic dermatitis susceptibility under the recessive model in the Association population. However, only three case-control studies [20, 30, 37] were enrolled in this comparison, and P value of HWE < 0.05 in controls of two studies [20, 37] were detected.…”

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

“…Other genes involved in immune functions, such as IL2RA [13,76], IL4 and ADAM33 [84], TGFB1 [57], and MIF promoter [42] have also been significantly associated to increased risk of AD. The relationship of TLRs polymorphisms with AD, i.e., TLR2 rs55743708(G>A) and TLR4 rs4986790(A>G) were reported to increase levels of IL-4 and IL-10 in Russian AD patients [61], while other authors found no association of TLR2 polymorphisms, i.e., rs5743708 and rs4696480, in Turkish children with AD [69].…”

“…Thus, COL5A3, COL6A6, and MMP9 are important for the collagen formation [145][146][147]; KDR, one of the two receptors of the VEGF, has been associated with integrin cell surface interactions with extracellular matrix [148]; mutations in STS (steroid sulfatase) have been associated to X-linked ichthyosis [148]; rare variants of MCM10, a key component of the pre-replication complex, have been described for the first time associated to AD [81]. Regarding TGF-β1 [57], besides its roles in other pathways, different works have shown its role in extracellular matrix assembly and disassembly [149,150]. Some genes associated to AD have been related to innate immune system pathways, providing solid evidences of the relationship of the innate immune system with the disease and its progression.…”