Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis

Qi, Yuqing; Kong, Jie; He, Jian‐Qing

doi:10.1186/s12881-019-0817-8

Cited by 12 publications

(10 citation statements)

References 43 publications

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“…Subgroup meta‐analyses revealed ethnicity‐specific effects. Similarly, Qi et al 7 . found no strong evidence to support a relationship between the three IL10 SNPs (I‐1082 A/G, –592 A/C and –819 T/C) and susceptibility to AE.…”

Section: Risk Factorsmentioning

confidence: 93%

See 1 more Smart Citation

What’s new in atopic eczema? An analysis of systematic reviews published in 2019. Part 1: Risk factors and prevention

Earp¹,

Tsianou

Grindlay

et al. 2021

Clin Exp Dermatol

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Summary This review is part of an annual evidence update on atopic eczema (AE), providing a summary of key findings from 18 systematic reviews published in 2019 on AE risk factors and prevention. Parental atopy, particularly AE, is a risk factor for offspring AE, and this risk is augmented both by the number of parental atopic diseases present and the number of affected parents. Low‐quality evidence suggests that autumn or winter birth increases childhood AE risk compared with birth in spring. There is some evidence to support filaggrin gene–environment interactions; however, this is limited by small underpowered studies. There is no evidence to suggest that polymorphisms in the –1082, –592 and –819 loci of the interleukin‐10 gene increase susceptibility to AE. There is no robust evidence to support a relationship between childhood AE development and either yoghurt consumption in the first year of life, gut microbiota variants, prenatal or infantile paracetamol exposure, maternal antibiotic exposure or air pollution. Three systematic reviews investigated the effect of probiotics given during pregnancy or infancy; although low‐quality evidence suggests benefits of combined probiotics, these studies were limited by significant heterogeneity. No relationship between the age at which complementary food and beverages are introduced and the risk of developing AE in infancy was identified. Consistent evidence showed no relationship between human milk feeding and infant AE development, aside from limited evidence suggesting a protective role in those with atopic heredity. This summary of recent evidence related to AE risk factors and prevention highlights the complex aetiology of AE.

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Section: Risk Factorsmentioning

confidence: 93%

“…Two SRs and meta‐analyses investigated the association between genetic polymorphisms within the interleukin (IL)‐10 gene ( IL10 ) and susceptibility to AE 7,8 . Both SRs investigated the same IL‐10 gene loci, and 13 overlapping case–control studies were identified.…”

Section: Risk Factorsmentioning

confidence: 99%

What’s new in atopic eczema? An analysis of systematic reviews published in 2019. Part 1: Risk factors and prevention

Earp¹,

Tsianou

Grindlay

et al. 2021

Clin Exp Dermatol

View full text Add to dashboard Cite

show abstract

“…Four studies described results from next-generation sequencing (NGS) [85][86][87][88], and 2 showed analyses of copy number variations (CNV) [89,90]. Besides, 6 meta-analyses were also included [91][92][93][94][95][96]. A description of the 64 selected non-epigenetic studies is presented in Table 1.…”

Section: Selection Bias and Quality Of Articlesmentioning

confidence: 99%

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

Martı́n

Estravís

Garcı́a-Sánchez

et al. 2020

Genes

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Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15–20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high prevalence makes it necessary to periodically compile and update the new information available. In this systematic review, the focus is set at the genetic and epigenetic studies carried out in the last years. Methods: A systematic literature review was conducted in three scientific publication databases (PubMed, Cochrane Library, and Scopus). The search was restricted to publications indexed from July 2016 to December 2019, and keywords related to atopic dermatitis genetics and epigenetics were used. Results: A total of 73 original papers met the inclusion criteria established, including 9 epigenetic studies. A total of 62 genes and 5 intergenic regions were described as associated with AD. Conclusion: Filaggrin (FLG) polymorphisms are confirmed as key genetic determinants for AD development, but also epigenetic regulation and other genes with functions mainly related to the immune system and extracellular matrix, reinforcing the notion of skin homeostasis breakage in AD.

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“…Referring to similar investigations [27,28], we collected potentially relevant studies from three databases, including PubMed, EMBASE (Excerpta Medica Database), and WOS (Web of Science), on 25 February 2020. To prevent the filtering of the possible eligible studies, in the retrieval strategy, we utilized a combination of subject words ["MeSH (medical subject headings)" for PubMed and "Emtree" for EMBASE] and free words ("Entry Terms" for PubMed, "synonyms" for EMBASE) in the retrieval strategy.…”

Section: Database Search and Study Identificationmentioning

confidence: 99%

Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Shi

et al. 2020

BMC Med Genet

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Background: Herein, we collected currently published data to comprehensively evaluate the impact of the FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases. Methods: We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses. Results: A total of fourteen case-control studies were included for FCGR2A rs1801274; while thirty-one case-control studies were included for MUC5B rs35705950. No significant difference between pneumonia cases and controls for FCGR2A rs1801274 was found. However, MUC5B rs35705950 was significantly associated with pneumonia susceptibility in the whole population under the genetic models of allelic T vs. G [OR (odds ratio) =3.78], carrier T vs. G (OR = 3.31), TT vs. GG (OR = 13.66), GT vs. GG (OR = 4.78), GT + TT vs. GG (OR = 5.05), and TT vs. GG + GT (OR = 6.47) (all P < 0.001, Bonferroni-adjusted P < 0.006; false discovery rate-adjusted P < 0.0010). Furthermore, we observed a similar positive result for subgroup analyses of "Caucasian", "Asian", "population-based control", and "idiopathic pulmonary fibrosis". Conclusions: MUC5B rs35705950, but not FCGR2A rs1801274, increases susceptibility to clinical pneumonia, especially to idiopathic pulmonary fibrosis, in both the Caucasian and Asian populations.

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Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis

Cited by 12 publications

References 43 publications

What’s new in atopic eczema? An analysis of systematic reviews published in 2019. Part 1: Risk factors and prevention

What’s new in atopic eczema? An analysis of systematic reviews published in 2019. Part 1: Risk factors and prevention

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

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