Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis

Chen, Minli; Zhao, Hua; Huang, Qiu-Pin; Xie, Zijian

doi:10.1007/s00405-018-4975-7

Cited by 13 publications

(14 citation statements)

References 45 publications

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“…The data of 10 SNPs were selected by using genotype data of Han Chinese in Beijing (CHB) and Japanese in Tokyo (JPT) from the 1000 Genomes Project (March 2012) and based on previously published studies. 12–17 , 28 , 29 Distributions of all genotypes in the control subjects were consistent with those estimated according to the minor allele frequency (MAF) > 0.05 and P- value of Hardy-Weinberg equilibrium (HWE) > 0.05. In addition, web-based tools were used to predict putative functions of genetic variants, including SNPinfo ( https://snpinfo.niehs.nih.gov/ ), HaploReg ( https://pubs.broadinstitute.org/mammals/haploreg/haploreg_v4.php ), RegulomeDB ( https://www.regulomedb.org/regulome-search/ ), MirSNP ( http://bioinfo.bjm-u.ed-u.cn/mirsnp/search/ ), and RNAhybrid ( https://bibiserv.cebitec.uni-bielefeld.de/rnahybrid/ ).…”

Section: Methodssupporting

confidence: 76%

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Chen¹,

Dai²,

Zhang³

et al. 2022

JIR

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Background Allergic rhinitis (AR) is a nasal inflammatory disease resulting from a complex interplay between genetic and environmental factors. The association between Toll-like receptor (TLR) signaling pathway and environmental factors in AR pathogenesis remains to be explored. This study aims to assess the genetic association of AR with single nucleotide polymorphisms (SNPs) in TLR signaling pathway, and investigate the roles of gene–gene and gene–environment interactions in AR. Methods A total of 452 AR patients and 495 healthy controls from eastern China were enrolled in this hospital-based case–control study. We evaluated putatively functional genetic polymorphisms in TLR2, TLR4 and CD14 genes for their association with susceptibility to AR and related clinical phenotypes. Interactions between environmental factors (such as traffic pollution, residence, pet keeping) and polymorphisms with AR were examined using logistic regression. Models were stratified by genotype and interaction terms, and tested for the significance of gene–gene and gene–environment interactions. Results In the single-locus analysis, two SNPs in CD14 , rs2563298 (A/C) and rs2569191 (C/T) were associated with a significantly decreased risk of AR. Compared with the GG genotype, the GT and GT/TT genotypes of TLR2 rs7656411 (G/T) were associated with a significantly increased risk of AR. Gene–gene interactions (eg, TLR2 rs7656411, TLR4 rs1927914, and CD14 rs2563298) was associated with AR. Gene–environment interactions (eg, TLR4 or CD14 polymorphisms and certain environmental exposures) were found in AR cases, but they were not significant after Bonferroni correction. Conclusion The genetic polymorphisms of TLR2 and CD14 and gene–gene interactions in TLR signaling pathway were associated with susceptibility to AR in this Han Chinese population. However, the present results were limited to support the association between gene–environment interactions and AR.

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Section: Methodssupporting

confidence: 76%

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Chen¹,

Dai²,

Zhang³

et al. 2022

JIR

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“…Although the IL ‐ 13 gene and genes coding for other cytokines have many variants that may also affect AD pathogenesis, we focused on one specific IL ‐ 13 variants to understand IL ‐ 13 gene‐antibiotic interactions. Since previous studies suggest that IL ‐ 13 (rs20541) is significantly associated with allergic risks especially in the Asian population, 9,11,28 this variant can be considered representative among IL ‐ 13 variants in this population. Nonetheless, for a complete understanding of the genetic basis for AD, various SNPs of different candidate genes should be investigated.…”

Section: Discussionmentioning

confidence: 99%

Effect of early‐life antibiotic exposure and IL‐13 polymorphism on atopic dermatitis phenotype

Park

Lee

et al. 2021

Pediatric Allergy Immunology

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Background: Although atopic dermatitis (AD) is associated with certain gene variants, the rapidly increasing incidence of AD suggests that environmental factors contribute to disease development. In this study, we investigated the association of AD incidence and phenotype with antibiotic exposure within 6 months of age, considering the dose administered and genetic risk.Methods: This study included 1637 children from the COCOA cohort. Pediatric allergists assessed the presence of AD at each visit and obtained information about antibiotic exposure for more than 3 days. IL-13 (rs20541) polymorphism was genotyped

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“…Since autoimmune diseases have a certain degree of similarity in immune imbalance and genetic background, a SNP is often found to be associated with multiple autoimmune diseases. Previous studies have found that rs2915863 is associated with symptomatic airway hyper-responsiveness, which may be related to endotoxin exposure and elevated IgE (34–36), and rs2569190 may contribute to allergic rhinitis (37), allergic asthma (24), and IBD (11). In this study, we, for the first time, found that rs2915863 and rs2569190 are significantly related to GD, especially in female patients.…”

Section: Discussionmentioning

confidence: 99%

Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population

et al. 2019

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Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirmed to be associated with a variety of autoimmune diseases. However, its relationship with AITDs is still unclear. The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT. The results showed significant association of rs2915863 and rs2569190 with GD. The frequencies of rs2915863 genotypes and T allele in patients with GD differed significantly from their controls (P = 0.007 and P = 0.021, respectively). For rs2569190, frequencies of genotypes and G allele in GD patients also showed positive P-values (P = 0.038 and P = 0.027, respectively). The correlations between these two loci and GD are more pronounced in female GD patients and patients with a family history. In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (P = 0.014, P = 0.015, P = 0.009, and P = 0.014, P = 0.001, P = 0.006, respectively). However, these four sites are not related to HT. We firstly discovered the relationship between CD14 gene polymorphism and GD, and the results indicate that CD14 is an important risk locus for AITD and its SNPs may contribute to host's genetic predisposition to GD.

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Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis

Abstract: Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.

Cited by 13 publications

References 45 publications

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Effect of early‐life antibiotic exposure and IL‐13 polymorphism on atopic dermatitis phenotype

Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population

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