Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk

Renner, Stefan P.; Strick, Reiner; Fasching, Peter A.; Oeser, Sonja; Oppelt, Peter; Mueller, Andreas; Beckmann, Matthias W.; Strissel, Pamela L.

doi:10.1016/j.ajog.2008.06.015

Cited by 18 publications

(9 citation statements)

References 60 publications

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“…Its prevalence can be as high as 40% in infertile women 12 – 15 and up to 87% in women with chronic pelvic pain. 16 , 17 There has also been concern regarding the association between endometriosis and malignancy—specifically ovarian cancer. 18 – 22 Patients with endometriosis also face the burden of high health costs before and after proper diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Strong Association Between Endometriosis and Symptomatic Leiomyomas

Nezhat

Abed

et al. 2016

JSLS

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Background and Objectives:The relationship between leiomyoma and endometriosis is poorly understood. Both contribute to considerable pain and may cause subfertility or infertility in women. We conducted this retrospective study to assess the rate of coexistence of endometriosis in women with symptomatic leiomyoma. The primary outcome measured was the coexistence of histology-proven endometriosis in women with symptomatic leiomyoma.Methods:This is a retrospective review of a data-based collection of medical records of 244 patients treated at a tertiary medical center, who were evaluated for symptomatic leiomyoma from March 2011 through December 2015. Of those, 208 patients underwent laparoscopic or laparoscopic-assisted myomectomy or hysterectomy. All patients provided consent for possible concomitant diagnosis and treatment of endometriosis. The remaining 36 patients underwent medical therapy and were excluded from the study. All patients who had myomectomy or supracervical hysterectomy underwent minilaparotomy for extracorporeal morcellation and specimen removal beginning in April 2012.Results:Of the 208 patients with the presenting chief concern of symptomatic leiomyoma and who underwent surgical therapy, 181 had concomitant diagnoses of leiomyoma and endometriosis, whereas 27 had leiomyoma. Of the 27 patients, 9 also had adenomyosis. Patients with only fibroid tumors were, on average, 4.0 years older than those with endometriosis and fibroids (mean age, 44 vs 40 ± SD). Patients with both pathologies were also more likely to present with pelvic pain and nulliparity than those with fibroid tumors alone.Conclusions:In our patient population, 87.1% of patients with a chief concern of symptomatic fibroids also had a diagnosis of histology-proven endometriosis, which affirms the need for concomitant diagnosis and intraoperative treatment of both conditions. Overlooking the coexistence of endometriosis in women with symptomatic leiomyoma may lead to suboptimal treatment of fertility and persistent pelvic pain. It is important for physicians to be aware of the possibility of this association and to thoroughly evaluate the abdomen and pelvis for endometriosis at the time of myomectomy or hysterectomy in an effort to avoid the need for reoperation.

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Section: Introductionmentioning

confidence: 99%

Strong Association Between Endometriosis and Symptomatic Leiomyomas

Nezhat

Abed

et al. 2016

JSLS

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“…Nevertheless, the therapeutic benefit of progesterone in patients with endometriosis is well known. The beneficial effect seems to be mediated by the progesterone receptor with a different expression in healthy patients and in patients with endometriosis (39,40). Furthermore, progesterone is known as a potential inhibitor of MMP expression in human endometrium (7).…”

Section: Discussionmentioning

confidence: 98%

Matrix metalloproteinase messenger RNA expression in human endometriosis grafts cultured on a chicken chorioallantoic membrane

Juhasz-Böss

Hofele

Lattrich

et al. 2010

Fertility and Sterility

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“…It was assumed that PR-B, with a nontranscriptional mechanism, provokes cell development through interaction with estrogen receptor and stimulates Src/P21ras/ERK pathway. In investigating progesterone receptor on uterine myoma, Renner, et al 14 found that +331G/A genotype was related to endometriosis incidence in myoma patients, which means this genotype was found more common in myoma patients having endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis

Alkaf

Chakra

Said

et al. 2016

Indones J Obstet Gynecol

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Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p

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Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk

Cited by 18 publications

References 60 publications

Strong Association Between Endometriosis and Symptomatic Leiomyomas

Strong Association Between Endometriosis and Symptomatic Leiomyomas

Matrix metalloproteinase messenger RNA expression in human endometriosis grafts cultured on a chicken chorioallantoic membrane

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis

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