Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis

Abstract

Objective: To identify relationship between progesterone receptor
 gene polymorphism promoter region +331G/A with the risk of
 endometriosis.
 Method: An observational case-control study. Population are women
 with endometriosis and/or adenomyosis who have been performed
 laparotomy/laparoscopy at Obstetrics and Gynecology
 Department Dr. Mohammad Hoesin General Hospital Palembang,
 January-November 2013. Subjects fulfilled inclusion criteria, given
 informed consent and performed blood sampling continued by PCRRFLP.
 Results were divided into A/A genotype (homozygote mutant),
 G/A (heterozygote mutant), and G/G (homozygote wild type).
 Data were analyzed by SPSS 21.0 version.
 Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in
 case group and 14 (26.4%) in control. +331A/A genotype was not
 found in both groups. There was significant increase risk of endometriosis
 in women carrying genotype +331G/A to those with genotype
 +331G/G with OR 3.29 (p

The Association between Aromatase Gene Polymorphism Cyp19 Val 80 and Endometriosis Risk

“…Within periods of January to November 2013, there were 101 subjects, 48 in case group and 53 in control group in previous study. 10 Our study used strict criteria for the definition of cases and controls. Women with endometriosis and/or adenomyosis included in this study were already proved by surgical (laparotomy or laparoscopy findings).…”