2015
DOI: 10.1590/1516-635x1704497-502
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Single Nucleotide Polymorphisms in IGFBP-2 Gene and Their Associations with Body Weight Traits on Jinghai Yellow Chicken

Abstract: Insulin-like growth factor binding protein-2 (IGFBP-2) regulates a broad spectrum of biological activities involved in growth, development, and differentiation. This study aimed at comparing polymorphisms in intron2 of the IGFBP-2 gene among four chicken breeds and at analyzing the associations between its genotypes and body weight in Jinghai Yellow chicken by using PCR-SSCP technique. For primer P2, three genotypes (AA, AB and BB) were observed in the four chicken breeds. Gene sequencing revealed one insertio… Show more

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Cited by 12 publications
(13 citation statements)
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“…In another study carried out by these researchers, intron 2 region of IGFBPII gene was studied in this population and three genotypes of AA, AB and BB (equivalent to CC, CT and TT in the Mazandaran native fowls population) were detected and no significant correlation was found between genotypes and body weight at 4, 8, 12 and 16 weeks of age. Also, mean comparisons analysis indicated that AA genotypes had higher body weight at 12 weeks of age than other genotypes and it was concluded that the A allele had a positive effect on body weight [24]. In the present study, three genotypes of CC, CT and TT were found with the frequency of 0.14, 0.62 and 0.24, respectively, in Mazandaran native fowls population, and the genotypic frequency of CT was significantly higher than the other two genotypes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In another study carried out by these researchers, intron 2 region of IGFBPII gene was studied in this population and three genotypes of AA, AB and BB (equivalent to CC, CT and TT in the Mazandaran native fowls population) were detected and no significant correlation was found between genotypes and body weight at 4, 8, 12 and 16 weeks of age. Also, mean comparisons analysis indicated that AA genotypes had higher body weight at 12 weeks of age than other genotypes and it was concluded that the A allele had a positive effect on body weight [24]. In the present study, three genotypes of CC, CT and TT were found with the frequency of 0.14, 0.62 and 0.24, respectively, in Mazandaran native fowls population, and the genotypic frequency of CT was significantly higher than the other two genotypes.…”
Section: Discussionmentioning
confidence: 99%
“…The insulin-like growth factor binding protein II gene (IGFBPII) has the size of approximately 38 kbp that is located on chromosome 7, entailing four short exons and three long introns and also contains 275 amino acids [22]. In indigenous and commercial chicken populations, significant associations of this gene were reported with body weight at the time of hatch and days 7, 14, 21, and 28 of age [22], growth rate at 4-8 and 8-12 weeks of age in hens and 0-4 weeks of age in rosters [23], and body weight at the time of hatch and 12 weeks of age [24]. Moreover, some SNPs have been detected to have significant effect on growth traits in indigenous chickens such as a SNP (C/T) in intron 2 on body weight at 2-12 weeks of age, length and weight of metatartos, shank, femur regions and abdominal fat weight [25], and also a SNP (1196CA) in 3'-flanking region on abdominal fat mass and its percentage [26].…”
Section: The Insulin-like Growth Factor Binding Protein IImentioning
confidence: 99%
“…57 However, PCR-SSCP was considered as a cornerstone in recent post-PCR genotyping studies on poultry, such as egg-production traits, body weight characteristics, and intramuscular fat content. [58][59][60] Because of its powerful ability to identify unknown SNP(s), Table 1. The Main Differences Between PCR-RFLP and PCR-SSCP Methods…”
Section: Applicationsmentioning
confidence: 99%
“…[62][63][64] With respect to fish and amphibians, species identification and the detection of environmental samples and closely related organisms were recently conducted using PCR-RFLP. [56][57][58][59][60][61][62][63][64][65][66][67][68] The PCR-SSCP was used in the detection of parasite species. 69 The ease of the use of PCR-RFLP was demonstrated in its successful implementation in species identification and discrimination in algae, bacteria, and fungi.…”
Section: Parameter Of Comparison Pcr-rflp Pcr-sscpmentioning
confidence: 99%
“…Previous studies have shown that some Single Nucleotide Polymorphisms (SNP) of IGFBP2 significantly affected growth traits (Lei et al, 2005;Sri-Sudaryati et al, 2013;Zhao et al, 2015). Leng et al (2009) reported that a polymorphism of IGFBP2 in the 3;-flanking region was associated with abdominal fat.…”
Section: Introductionmentioning
confidence: 99%