Single nucleotide polymorphisms and haplotypes in the gene for vascular endothelial growth factor and risk of prostate cancer

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

“…These data suggest that the low frequency of A/A carriers in the cases group observed in our study was directly related with their status of disease. Worldwide, there are two previous case-control studies evaluating the relationship between -2578 C/A VEGF SNP and PCa risk in U.S. and Austrian men, respectively [7,30]. Conversely to our findings, negative results for this association were reported in both protocols, reflecting the influence of inter-population genetic variability.…”

“…Mechanisms such as production of pro-angiogenic molecules, activation of the endothelium, the capillary wall degradation, and migration of endothelial cells are essential in the angiogenesis processes and therefore in the tumor progression [6]. The vascular endothelial growth factor (VEGF) is the most important member of a family of ligands with 40% to 80% of homology (VEGF-A, B, C, D, and placental growth factor respectively), is also a hypoxia-induced gene, and has a potent vascular permeability function [5,7]. VEGF-A (also called VEGF) induces endothelial cell division, locomotion/migration, survival, and endothelial progenitor cells mobilization from the bone marrow to sites of active angiogenesis [7,8].…”

“…The vascular endothelial growth factor (VEGF) is the most important member of a family of ligands with 40% to 80% of homology (VEGF-A, B, C, D, and placental growth factor respectively), is also a hypoxia-induced gene, and has a potent vascular permeability function [5,7]. VEGF-A (also called VEGF) induces endothelial cell division, locomotion/migration, survival, and endothelial progenitor cells mobilization from the bone marrow to sites of active angiogenesis [7,8]. VEGF is expressed by several tumors at higher levels than when it appears in normal tissues, and its over-expression suggests unfavorable prognosis [8][9][10].…”

Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients

“…It is reported that VEGF is overexpressed in RCC tissues when compared with normal renal tissues (Langsenlehner et al, 2008). Therapeutic targeting of VEGF has shown preliminary clinical efficacy in RCC (Jäkel et al, 2012;Vrdoljak et al, 2013).…”

Synergistic effect and VEGF/HSP70-hom haplotype analysis: Relationship to prostate cancer risk and clinical outcome

“…Alleles within such ancestrally preserved haplotype blocks tend to be in strong linkage disequilibrium with one another at the level of population, and variations in haplotypes may be powerful predictors of disease. The genes encoding the HSP70-hom and VEGF are closely linked on the short arm of chromosome 6p21 and have been implicated as candidate genes for PCa [7][8][9][10][11].…”