Synergistic effect and VEGF/HSP70-hom haplotype analysis: Relationship to prostate cancer risk and clinical outcome

Sfar, Sana; Saad, H.; Mosbah, Faouzi; Chouchane, Lotfi

doi:10.1016/j.humimm.2010.01.017

Cited by 10 publications

(4 citation statements)

References 56 publications

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“…As for the HSP70-2 and HSP70-hom polymorphisms, the HSP70-2 A+1267G polymorphism is a synonymous mutation located at the coding region and is likely to affect the secondary structure of mRNA, thus affecting the stability of mRNA and protein expression, and the HSP70-hom T > C polymorphism has nonsynonymous mutations, which leads to a Met to Thr substitution at position 493 in the peptide binding domain and may affect substrate binding specificity and chaperone activity of HSP70 [6]. Some investigations demonstrated that genetic alteration of the HSP70-2 and/or HSP70-hom can modulate cancer susceptibility and that the frequency of the variant genotype was significantly higher in patients when compared with controls [11, 12, 18, 22]. However, the association of Ala variants and cancer risk was not validated by others [16, 21, 25, 27, 28].…”

Section: Discussionmentioning

confidence: 99%

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

Deng

Luo

2014

The Scientific World Journal

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The polymorphisms in the three main heat shock protein 70 (HSP70-1, HSP70-2, and HSP70-hom) genes were identified to be associated with cancer risk. However, the results are inconsistent. We perform a meta-analysis to evaluate the association between the three HSP70 polymorphisms and cancer risk. Relevant studies were identified using PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases up to March 29, 2014. The cancer risk associated with the HSP70 polymorphisms was estimated for each study by odds ratios (OR) together with its 95% confidence interval (CI), respectively. Twenty case-control studies from eighteen publications were included; a significant association was observed for HSP70-2 polymorphism (dominant model: OR = 1.53, 95% CI: 1.11–2.09; recessive model: OR = 1.91, 95% CI: 1.06–3.45; AG versus AA: OR = 1.38, 95% CI: 1.03–1.84; GG versus AA: OR = 2.34, 95% CI: 1.21–4.54), while there was no significant association for HSP70-1 and HSP70-hom polymorphisms. Besides, in stratification analyses by ethnicity, cancer type, and source of control, significant association was detected for HSP70-2 polymorphism, while for HSP70-hom polymorphism, we found a significant association in hospital-based population under homozygote comparison model. This meta-analysis suggests that the HSP70-2 polymorphism rather than HSP70-hom and HSP70-1 polymorphisms was associated with the risk of cancer.

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Section: Discussionmentioning

confidence: 99%

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

Deng

Luo

2014

The Scientific World Journal

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“…However, in BRCA1 carriers the low-VEGF T-allele confers protection from disease (Jakubowska et al 2008). Similarly, although large case-control studies have failed to find an association between prostate cancer risk and VEGF polymorphisms (Jacobs et al 2008), when gene-gene interactions are considered, several smaller studies have shown that VEGF polymorphisms can play a role in disease risk or aggressiveness (Sfar et al 2010; VanCleave et al 2010).…”

Section: Common Polymorphisms In Angiogenesismentioning

confidence: 99%

Common Polymorphisms in Angiogenesis

Rogers

D’Amato

2011

Cold Spring Harbor Perspectives in Medicine

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“…3 Recent studies suggest that genetic polymorphisms of genes involved in prostate angiogenesis may confer susceptibility to PCa. [4][5][6] Angiogenesis is essential for tumor development and metastasis, and in various types of tumors, including urological malignancies, it has been reported that angiogenesis was closely associated with advanced disease status and poor prognosis. 7,8 The hypoxia-inducible factor-1 (HIF-1) plays an important role in regulating angiogenesis, cell adhesion, metastatic spread and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population

Cao²,

Shao³

et al. 2012

Asian J Androl

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The hypoxia-inducible factor-1α (HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIF1A (coding HIF-1α) have been shown to influence an individual's susceptibility to many human tumors; however, evidence on associations between HIF1A single-nucleotide polymorphisms (SNPs) and prostate cancer (PCa) risk is conflicting. We genotyped three potentially functional polymorphisms in HIF1A (rs11549465, rs11549467 and rs2057482) using the TaqMan method and assessed their associations with PCa risk in a case-control study of 662 PCa patients and 716 controls in a Chinese Han population. Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89). Furthermore, patients with rs11549467 variant genotypes were associated with a higher Gleason score (OR=2.14; 95%CI=1.22-3.75). No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism. However, the combined variant genotypes of rs2057482 and rs11549467 were associated with increased PCa risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles). These results suggest that HIF1A polymorphisms may impact PCa susceptibility and progression in the Chinese Han population.

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Synergistic effect and VEGF/HSP70-hom haplotype analysis: Relationship to prostate cancer risk and clinical outcome

Cited by 10 publications

References 56 publications

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

Common Polymorphisms in Angiogenesis

Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population

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