Single-nucleotide polymorphisms among microRNA: big effects on cancer

Song, Feng; Chen, Kexin

doi:10.5732/cjc.011.10142

Cited by 26 publications

(19 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Genetic variations, mostly SNPs within miRNA-processing genes, miRNA sequences and miRNA-binding sites, have been found to be associated with various types of cancers. These three types of SNPs could affect cancer risk [[30]]. In recent years, increasing research has indicated a close relationship between SNPs in microRNA regulatory genes and the genetic susceptibility to primary liver cancer [[31]].…”

Section: Introductionmentioning

confidence: 99%

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Chu

Duan

et al. 2014

Cell Commun Signal

View full text Add to dashboard Cite

The pathogenesis of hepatocellular carcinoma (HCC) is not fully understood, which has affected the early diagnosis and treatment of HCC and the survival time of patients. MicroRNAs (miRNAs) are a class of evolutionarily conserved small, non-coding RNAs, which regulate the expression of various genes post-transcriptionally. Emerging evidence indicates that the key enzymes involved in the miRNA biosynthesis pathway and some tumor-specific miRNAs are widely deregulated or upregulated in HCC and closely associated with the occurrence and development of various cancers, including HCC. Early studies have shown that miRNAs have critical roles in HCC progression by targeting many critical protein-coding genes, thereby contributing to the promotion of cell proliferation; the avoidance of apoptosis, inducing via angiogenesis; and the activation of invasion and metastasis pathways. Experimental data indicate that discovery of increasing numbers of aberrantly expressed miRNAs has opened up a new field for investigating the molecular mechanism of HCC progression. In this review, we describe the current knowledge about the roles and validated targets of miRNAs in the above pathways that are known to be hallmarks of HCC, and we also describe the influence of genetic variations in miRNA biosynthesis and genes.

show abstract

Section: Introductionmentioning

confidence: 99%

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Chu

Duan

et al. 2014

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

“…Although miRNAs constitute only 1% to 3% of the human genome, they are estimated to control approximately 30% of all coding genes in the human genome[2]–[4]. At present, over 1000 miRNAs have been identified in humans according to miRBase[5].…”

mentioning

confidence: 99%

The expression and functions of microRNAs in pancreatic adenocarcinoma and hepatocellular carcinoma

Li¹,

LeBrun²,

Li³

2011

Chin J Cancer

View full text Add to dashboard Cite

Pancreatic adenocarcinoma and hepatocellular carcinoma are devastating human malignancies that are characterized by poor prognosis, late onset, and a lack of known biomarkers. New diagnostic and therapeutic molecular targets are desperately needed to develop novel and effective treatment strategies. MicroRNAs (miRNAs) are an emerging class of molecules with roles in various cellular processes, including growth, survival, and apoptosis. Most importantly, aberrant expression of miRNAs has been implicated in cancer pathogenesis. miRNA expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma indicate selective overexpression of oncogenic miRNAs and down-regulation of tumor suppressive miRNAs in these cancers. This review summarizes results from key studies conducted to characterize the miRNA expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma and describes the potential mechanisms by which some oncogenic or tumor suppressive miRNAs act. Furthermore, this review outlines novel therapeutic strategies for targeting miRNAs.

show abstract

“…12 Perkembangan dalam teknologi kuantifikasi miRNA, seperti miRNA microarray, bead-based flow cytometry, RNA-primed array-based Klenow enzyme (RAKE) assay, miRNA serial analysis of gene expression (miRAGE), and realtime RT-PCR based TaqMan miRNA assay telah memfasilitasi studi profil miRNA global pada genom kanker. 13 MiRNA dapat menjadi penanda molekuler yang akurat karena relatif stabil mengingat ukurannya yang kecil dan resisten terhadap degradasi RNAse. miRNA dapat diisolasi dari spesimen formalin-fixed paraffin-embedded (FFPE) dan dikuantifikasi dengan qRT-PCR dan microarray.…”

unclassified

“…Lebih dari setengah gen-gen miRNA pada manusia berlokasi pada daerah genomik yang sering mengalami amplifikasi, delesi, dan translokasi terlibat dalam kanker. 13,15,16 Bukti pertama keterlibatan miRNA dalam kanker dilaporkan pada 2002, saat Calin menemukan dua gen miRNA yaitu miR-15a dan miR-16-1 pada daerah di kromosom 13q14 yang biasanya mengalami delesi pada leukemia limfositik kronik. Hilangnya miR-15a dan miR-16-1 terjadi pada hampir 70% leukemia limfositik kronik.…”

unclassified

“…Hilangnya miR-15a dan miR-16-1 terjadi pada hampir 70% leukemia limfositik kronik. 13 Delesi atau penurunan ekspresi miR-15a dan miR-16-1 juga ditemukan pada kanker prostat, limfoma, dan mieloma multipel. 16 Kemajuan dalam bidang penelitian kanker memberikan informasi bahwa kelainan regulasi ekpresi miRNA ditemukan pada sejumlah kanker manusia seperti leukemia, limfoma, glioblastoma, kanker kolon, kanker paru, kanker payudara, kanker prostat, kanker tiroid, kanker serviks, dan kanker ovarium.…”

unclassified

See 1 more Smart Citation

The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer

Wargasetia¹

2016

Journal of Medicine and Health

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell and their deregulation plays an important role in cancer development and progression. In this review, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalities in cellular pathways that led to transformation of normal cells into cancer cells, as well as the indication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, as biomarkers to predict the response to cancer therapy and the potential for development of miRNAs as cancer targeted therapy. AbstrakMicroRNA (MiRNA) terlibat dalam regulasi penyampaian pesan dalam sel dan kelainan pada regulasi miRNA berperan penting dalam perkembangan dan progresi kanker. Pada tulisan ini dibahas mengenai biogenesis miRNA, fungsi miRNA, dan efek kelainan regulasi miRNA pada jalur di dalam sel yang mengarah kepada konversi sel normal menjadi sel kanker. Juga dibahas indikasi miRNA sebagai biomarker diagnosis dan prognosis berbagai kanker, biomarker untuk prediksi respons terapi kanker, serta potensi untuk mengembangkan terapi kanker dengan miRNA sebagai target. PendahuluanMicroRNA (miRNA) adalah asam ribonukleat yang tidak mengkode protein dengan transkrip akhir sepanjang 18-25 nukleotida yang berinteraksi dengan target gen yang mengkode mRNA. miRNA bekerjasama dengan elemen pengatur lain seperti faktor transkripsi untuk mengontrol translasi mRNA. 1 Kebanyakan miRNA dikode pada bagian genom yang dulu dianggap sebagai daerah bukan pengkode. Sejak ditemukan pertama kali di tahun 1993 pada cacing Caenorhabditis elegans 2 , miRNA menarik perhatian karena ciri fungsional yang unik dan cara kerjanya, memberi sebuah dimensi baru terhadap dogma sentral biologi molekuler. 3,4 Gen-gen miRNA tersebar di dalam genom dan diperkirakan berjumlah 2-5% dari gen-gen manusia. 2 MiRNA sering diekspresikan sebagai transkrip polisistronik. 5 Satu miRNA dapat mempunyai banyak mRNA target sehingga diperkirakan bahwa lebih dari 1/3 gen-gen manusia diatur oleh miRNA. 3 Dewasa ini lebih dari 1.500 miRNA telah dikarakterisasi dan jumlah gengen yang telah diketahui diatur oleh miRNA pada manusia telah meningkat pesat. 6,7 Kurang lebih sepertiga miRNA pada manusia berada dalam 113 kelompok yang terdiri dari 2-7 gen dengan jarak antar gen miRNA dalam kelompok yang sama adalah ≤ 51 kb. Data profil miRNA dari berbagai jaringan dan lini sel memperlihatkan kelompok-kelompok miRNA tersebut diekspresikan bersama-sama. 5,8 Gen-gen miRNA lainnya dipotong dari intron gen-gen pengkode protein, intron dan ekson dari gen bukan pengkode protein, atau dari 3'-UTR gen-gen pengkode protein dan diekspresikan secara individual. 8Peran miRNA sebagai molekul pengatur utama yang mengontrol berbagai proses dasar dalam sel, seperti proliferasi, kematian, diferensiasi, apoptosis, motilitas, sifat invasif, respons terhadap stres dan sebagainya terus dipelajari di hampir semua lingkup biologi dan biomedis. 3,9 Pada tulisan ini dibahas biogenesis miRNA, fungsi miRNA, dan kelainan regulasi miRNA pada p...

show abstract

Single-nucleotide polymorphisms among microRNA: big effects on cancer

Cited by 26 publications

References 121 publications

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

The expression and functions of microRNAs in pancreatic adenocarcinoma and hepatocellular carcinoma

The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer

Contact Info

Product

Resources

About