Single-nucleotide Polymorphism in the CD14 Promoter and Periodontal                Disease Expression in a Japanese Population

Yamazaki, Kazuhisa; Ueki-Maruyama, K.; Oda, Tomoko; Tabeta, Koichi; Shimada, Yukiyasu; Tai, Hideaki; Nakajima, Takako Eguchi; Yoshie, Hiromasa; Herawati, Dahlia; Seymour, G. J.

doi:10.1177/154405910308200808

Cited by 39 publications

(36 citation statements)

References 29 publications

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“…49 CD14 may be especially useful as a marker if future therapies alter the CD14/TLR4 signaling pathway. In addition, it remains to be determined whether functional polymorphisms within CD14 gene (e.g., its promoter) 50 influence specific PKD outcomes.…”

Section: Discussionmentioning

confidence: 99%

Renal CD14 expression correlates with the progression of cystic kidney disease

Zhou

Ouyang

Cui

et al. 2010

Kidney International

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Monocyte and macrophage markers are among the most highly overexpressed genes in cpk mouse kidneys with severely progressive renal cystic disease. We now demonstrate that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys. However, these abnormalities are not associated with an increased number of interstitial CD14-positive mononuclear cells. Instead, we show that most non-cystic and cystic renal tubular epithelia are CD14-positive and that CD14 can be produced even by distal nephron-derived principal cells. Cd14 overexpression is significant in as early as 5-d old sporadically cystic cpk kidneys and it further increases during the disease progression. Similarly, in a cpk model with variable rates of cystic kidney disease progression, a (C57BL/6J-cpk × CAST/Ei)F1 intercross, Cd14 expression positively correlates with kidney volume in 10-d old mice, exceeding the correlation of a gene encoding an established autosomal dominant polycystic kidney disease (ADPKD) marker, MCP-1 (r=0.94 vs. r=0.79; both p<0.001). Similarly, in a small group of ADPKD patients (n=16), baseline urinary CD14 levels (but not GFR) correlate with a two-year rate of total kidney volume change (overall r=0.43, p=0.09; for males r=0.74, p=0.02) suggesting potential utility of CD14 in predicting ADPKD outcomes.

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Section: Discussionmentioning

confidence: 99%

Renal CD14 expression correlates with the progression of cystic kidney disease

Zhou

Ouyang

Cui

et al. 2010

Kidney International

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“…Eight studies have investigated the CD14 -260 polymorphism in Caucasian CP subjects (Table 11), but the results are conflicting. Two studies found an association with the N -allele and another study with the R -allele whereas five studies did not find any association with the CP susceptibility [87, 93]. …”

Section: Candidate Genes In Relation To Chronic Periodontitis (Cp)mentioning

confidence: 99%

Gene Polymorphisms in Chronic Periodontitis

Laine

Loos

Crielaard

2010

International Journal of Dentistry

109

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We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare (R)-allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.

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“…Recent case-control studies of our group [7][8][9][10][11][12][13][14][15][16] in Japanese population are summarized in Table 2 and Fig. 1.…”

Section: Aggressive Periodontitismentioning

confidence: 96%