Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma

No association between <i>Vitamin D receptor</i> gene polymorphisms and nasopharyngeal carcinoma in a Chinese Han population

“…NPC is a malignancy arising from the epithelial cells lining the nasopharynx and it often occurs in Southern China and Southeast Asia. Our previous studies and other studies have shown that a range of cytokines (7,8), including IL-1B, interleukin-8, interleukin-10, and transforming growth factor-b1 gene polymorphisms, may contribute to the development of NPC. Therefore, in combination with the correlation with VDR gene alteration and cancer risk, we postulate that VDR Fok I and Bsm I gene polymorphisms may modulate susceptibility to NPC.…”

“…In our previous studies, we have found that gene polymorphisms of some cytokines may contribute to the development of NPC (7,8), such as interleukin-1B, interleukin-8, interleukin-10, and transforming growth factor-b1. Therefore, we hypothesized that VDR gene polymorphisms may also be involved in modulating susceptibility to NPC.…”

“…However, the molecular mechanism of NPC pathogenesis is not yet well known. An abundance of recent research has shown single-nucleotide polymorphisms (SNP), such as cytochrome P450 2E1 (CYP2E1) (5), cyclin D1 (6) and a series of cytokines involved in the development of NPC (7,8), which indicated that NPC carcinogenesis may be due to genetic differences such as SNP.…”

Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

“…Additionally, increased levels of IL-8 in proliferative diabetic retinopathy were reported to be associated with a higher extent of large-vessel gliotic obliteration [20]. The tested polymorphisms of IL-8 and IL-18 (1633T/C, 251A/T, 607C/A, 137G/C) have recently been reported to be associated with various forms of cancer [20][21][22][23][24][25]. Moreover, the -607C/A and the -137G/C polymorphisms of the IL-18 gene were reported to be associated with susceptibility to type 1 diabetes; the C allele of-137 polymorphism was found to be a risk allele for DR and the A allele of -607 was found to be a protective allele against DR [14].…”

Lack of Association Between Interleukin-8-251 T>A Polymorphism and Colorectal Cancer Risk: a Meta-analysis based on 3,019 Cases and 3,984 Controls

“…Several polymorphisms have been detected in the IL-8 gene, and a common polymorphism at the -251 position (251T>A) of the promoter region has been associated with transcriptional activity of the gene. The -251T>A polymorphism at the promoter region of IL-8 gene is associated with the transcriptional activity of the gene (Wei et al, 2007), and to influence production and expression of IL-8 (Ohyauchi et al, 2005;Taguchi et al, 2005).…”