No association between &lt;i&gt;Vitamin D receptor&lt;/i&gt; gene polymorphisms and nasopharyngeal carcinoma in a Chinese Han population

Huang, Xin; Cao, Zhiling; Zhang, Zhen; Yang, Yang; Wang, Jun; Fang, Dingzhi

doi:10.5582/bst.2011.v5.3.99

Cited by 19 publications

(13 citation statements)

References 23 publications

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“…Numerous studies have investigated the association between VDR polymorphisms and risk of cancers, mostly breast and prostate cancer, but the obtained data were not consistent and had low reproducibility between studies. A recent study has shown no association between VDRFokI and BsmI polymorphisms and risk of nasopharyngeal carcinoma in a Chinese Han population (33) which is in agreement with our results. It has been reported that VDR EcoRV EE mutant genotype compared with ee wild type genotype is associated with decreased risk of cutaneous melanoma (17).…”

Section: Discussionsupporting

confidence: 93%

Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival

Zeljić

Šupić

Stamenković‐Radak

et al. 2012

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 93%

Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival

Zeljić

Šupić

Stamenković‐Radak

et al. 2012

J Oral Pathology Medicine

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“…43 The distribution of at least 1 important vitamin D receptor polymorphism (FokI) is known to differ by race/ethnicity. 44–46 We recently observed that common genetic polymorphisms in the vitamin D receptor modify associations of serum 25(OH)D concentration with risk of a composite clinical outcome among older white adults, supporting the principle that genetic variation in the vitamin D receptor alters susceptibility to low 25(OH)D. 47 …”

Section: Discussionmentioning

confidence: 87%

Racial Differences in the Association of Serum 25-Hydroxyvitamin D Concentration With Coronary Heart Disease Events

Robinson‐Cohen¹,

Hoofnagle²,

Ix³

et al. 2013

JAMA

175

121

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“… 28 , 37 , 38 , 39 In contrast, FokI and Bsm I polymorphisms of vitamin D receptor gene, SNP of deleted in liver cancer-1 (−29A/T) showed no association with NPC. 40 , 41 However, polymorphisms in PIN-1, TNF-α and glutathione S -transferase genes are indirectly associated with NPC as they influence the p53 codon72 polymorphism. 42 , 43 , 44 These studies suggest that genetic predisposition may play a role in NPC development.…”

Section: Resultsmentioning

confidence: 99%

Association of p53 codon72 Arg>Pro polymorphism with susceptibility to nasopharyngeal carcinoma: evidence from a case–control study and meta-analysis

Sahu

Chakrabarti

Roy³

et al. 2016

Oncogenesis

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Tumor suppressor p53 is a critical player in the fight against cancer as it controls the cell cycle check point, apoptotic pathways and genomic stability. It is known to be the most frequently mutated gene in a wide variety of human cancers. Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC). However, the association of this polymorphism with NPC across the published literature has shown conflicting results. We aimed to conduct a case–control study for a possible relation of p53 codon72 Arg>Pro polymorphism with NPC risk in underdeveloped states of India, combine the result with previously available records from different databases and perform a meta-analysis to draw a more definitive conclusion. A total of 70 NPC patients and 70 healthy controls were enrolled from different hospitals of north-eastern India. The p53 codon72 Arg>Pro polymorphism was typed by polymerase chain reaction, which showed an association with NPC risk. In the meta-analysis consisting of 1842 cases and 2330 controls, it was found that individuals carrying the Pro allele and the ProPro genotype were at a significantly higher risk for NPC as compared with those with the Arg allele and the ArgArg genotype, respectively. Individuals with a ProPro genotype and a combined Pro genotype (ProPro+ArgPro) also showed a significantly higher risk for NPC over a wild homozygote ArgArg genotype. Additionally, the strength of each study was tested by power analysis and genotype distribution by Hardy–Weinberg equilibrium. The outcome of the study indicated that both allele frequency and genotype distribution of p53 codon72 Arg>Pro polymorphism were significantly associated with NPC risk. Stratified analyses based on ethnicity and source of samples supported the above result.

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No association between <i>Vitamin D receptor</i> gene polymorphisms and nasopharyngeal carcinoma in a Chinese Han population

Cited by 19 publications

References 23 publications

Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival

Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival

Racial Differences in the Association of Serum 25-Hydroxyvitamin D Concentration With Coronary Heart Disease Events

Association of p53 codon72 Arg>Pro polymorphism with susceptibility to nasopharyngeal carcinoma: evidence from a case–control study and meta-analysis

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