Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy

Abstract

HIGHLIGHTS • Bi 2 Se 3 @AIPH nanoparticles (NPs) can realize photothermal and photodynamic therapies in a cascading manner when exposed to "one" single NIR laser. • Hyperthermia produced by Bi 2 Se 3 NPs under NIR laser irradiation cannot only be used for photothermal therapy, but also the "switch" for controlled release of AIPH and excitation of free radical at the tumor site. • Free radical produced by thermal-responsive decomposition of AIPH is oxygen-independent, which treats hypoxic tumor well and further enhances immune response.

Near‐Infrared II Light‐Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors

“…Second, currently available PTT/TDT nanosystems are mostly based on nondegradable inorganic nanoparticles (NPs), which may potentially result in long‐term systemic toxicity. [ 35,36 ] Thus, the development of degradable PTT/TDT combination therapeutic nanosystems active in the NIR II bio‐window is highly anticipated to achieve safe and efficient treatment of deep hypoxic tumors.…”

Recent Progress of Alkyl Radicals Generation‐Based Agents for Biomedical Applications

“…Li et al developed an NP that possessed CT imaging ability for therapy guidance. [100] Hollow Bi 2 Se 3 NPs were employed as the carriers, which were loaded with AIPH and lauric acid (PCM) to generate the final product (denoted as Bi 2 Se 3 @AIPH NPs). As illustrated in Figure 5a, upon 808 nm laser irradiation, the Bi 2 Se 3 @AIPH NPs can produce hyperthermia to kill cancer cells directly.…”

“…Reproduced with permission. [ 100 ] Copyright 2019, Springer Nature. e) Construction of Fe 5 C 2 ‐BSA‐AIPH/PCM.…”

“…To address this thorny problem, thermal-labile azo initiators such as 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (denoted as AIPH or AIBI), 2,2′-azobis[N-(2-carboxyethyl)-2-methylpropionamidine] hydrate (V057), and 2,2′-azobis[2methylpropionamidine] dihydrochloride (AIBA) have recently attracted researchers' interest (Scheme 1). [94][95][96][97][98][99][100] Upon thermal or ultrasound excitation, each of these initiators can be decomposed to give two alkyl radicals for killing cancer cells. Owing to the different molecular structure of these initiators, they show varied thermal stabilities.…”

NIR Light‐Driven Bi2Se3‐Based Nanoreactor with “Three in One” Hemin‐Assisted Cascade Catalysis for Synergetic Cancer Therapy

“…[ 16,17 ] Encouragingly, Bi 2 Se 3 is a NIR light‐responsive semiconductor with proper bandgap, good photothermal conversion ability, and biocompatibility. [ 18–20 ] Govinda et al. reported Bi 2 Se 3 /PEI NPs could generate ROS to eradicate the Staphylococcus aureus and Escherichia coli bacteria upon 808 nm laser irradiation.…”