Single Neuron Activity and Theta Modulation in Postrhinal Cortex during Visual Object Discrimination

Furtak, Sharon C.; Ahmed, Omar J.; Burwell, Rebecca D.

doi:10.1016/j.neuron.2012.10.039

Cited by 83 publications

(119 citation statements)

References 85 publications

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“…However, the anatomical data can also be interpreted as indicating that the functional segregation in the EC-CA1-subiculum pathway is not absolute, as the convergent LEC + MEC derived information from CA3 is passed onto all subregions of CA1. In addition, LEC and MEC are reciprocally connected (Dolorfo and Amaral 1998a), further supporting interactions between these pathways (Furtak et al 2012;Hunsaker et al 2013). …”

Section: Organization Of Connections In the Hippocampal Formationmentioning

confidence: 74%

Spatial and Nonspatial Representations in the Lateral Entorhinal Cortex

Deshmukh

2014

Space,Time and Memory in the Hippocampal Formation

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The hippocampus is thought to function as a "cognitive map," which stores nonspatial information such as items and events in a spatial framework. In order to understand the computations involved in creating such conjunctive nonspatial + spatial representations, it is essential to understand the function of hippocampal inputs. Medial entorhinal cortex (MEC) is known to convey spatial information to the hippocampus. In this chapter, we discuss recent evidence showing that lateral entorhinal cortex (LEC) conveys both spatial and nonspatial information to the hippocampus, in the presence of objects. Perirhinal cortex (PRC), a major cortical input to LEC, encodes nonspatial, object-related information, but does not encode spatial information in the presence of objects. Thus, the landmark-derived spatial information arises de novo in LEC. The classical dual-pathway model, in which LEC encodes nonspatial information while MEC encodes spatial information, cannot account for LEC spatial representation in the presence of objects. We propose that the functional difference between LEC and MEC is better understood in terms of the different inputs they use to create their representations: LEC generates spatial as well as nonspatial representations by processing external sensory inputs in contrast to MEC, which generates spatial representations by processing internally based path integration information.

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Section: Organization Of Connections In the Hippocampal Formationmentioning

confidence: 74%

Spatial and Nonspatial Representations in the Lateral Entorhinal Cortex

Deshmukh

2014

Space,Time and Memory in the Hippocampal Formation

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“…Similarly, LEC lesions primarily caused non-spatial deficits, but there were weak but significant spatial deficits. Physiologically, one synapse upstream from the entorhinal cortex, Furtak et al [40] showed that single units in the postrhinal cortex have both spatial and non-spatial correlates. Deshmukh & Knierim [35] demonstrated that a small but significant number of LEC cells (but not perirhinal cells; [41]) showed spatial firing that strongly resembled hippocampal place fields when there were objects present in the environment.…”

Section: Complications With the Simple 'What Versusmentioning

confidence: 99%

Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local–global reference frames

Knierim

Neunuebel

Deshmukh

2014

Phil. Trans. R. Soc. B

360

357

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The hippocampus receives its major cortical input from the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC). It is commonly believed that the MEC provides spatial input to the hippocampus, whereas the LEC provides non-spatial input. We review new data which suggest that this simple dichotomy between ‘where’ versus ‘what’ needs revision. We propose a refinement of this model, which is more complex than the simple spatial–non-spatial dichotomy. MEC is proposed to be involved in path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; it provides the hippocampus with a coordinate system that underlies the spatial context of an experience. LEC is proposed to process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about the content of an experience.

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“…Whether information regarding the distal and proximal framework is provided to postsynaptic targets in the parietal cortex by anterior and lateral thalamic outflow, respectively, is unknown, but remains a major possibility given the strong connectivity between these three regions (Wilber et al, 2015). With respect to the postrhinal cortex, recent work has shown that neurons within this region respond to proximal stimuli and local contextual cues (Furtak et al, 2012). It has been recently suggested that the lateral thalamus, through its dense projections, likely plays a role in visual information processing by postrhinal neurons .…”

Section: Summary Conclusion and Unanswered Questionsmentioning

confidence: 99%