Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory?

Clark, Benjamin J.; Harvey, Ryan E.

doi:10.1016/j.nlm.2016.06.002

Cited by 50 publications

(43 citation statements)

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“…The hippocampus has been a strong focus in AD research, despite various other limbic circuit structural involvement in AD 2 , 48 . It is currently unclear whether TgF344-AD pathology emerges in other limbic regions associated with spatial navigation, such as the anterior thalamic nuclei or retrosplenial cortex.…”

Section: Discussionmentioning

confidence: 99%

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris Water Task

Berkowitz

Harvey

Drake

et al. 2018

Sci Rep

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Spatial navigation is impaired in early stages of Alzheimer’s disease, and may be a defining behavioral marker of preclinical AD. A new rat model (TgF344-AD) of AD overcomes many limitations of other rodent models, though spatial navigation has not been comprehensively assessed. Using the hidden and cued platform variants of the Morris water task, a longitudinal assessment of spatial navigation was conducted on TgF344-AD (n = 16) and Fischer 344 (n = 12) male and female rats at three age ranges: 4 to 5 months, 7 to 8, and 10 to 11 months of age. TgF344-AD rats exhibited largely intact navigation at 4–5 months, with deficits in the hidden platform task emerging at 7–8 months and becoming significantly pronounced at 10–11 months of age. In general, TgF344-AD rats displayed less accurate swim trajectories to the platform and searched a wider area around the platform region compared to wildtype rats. Impaired navigation occurred in the absence of deficits in acquiring the procedural task demands or navigation to the cued platform location. Together, the results indicate that TgF344-AD rats exhibit comparable navigational deficits to those found in individuals with preclinical-AD.

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Section: Discussionmentioning

confidence: 99%

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris Water Task

Berkowitz

Harvey

Drake

et al. 2018

Sci Rep

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“…This coincides with the reported early incidence of pathology in humans associated with the entorhinal cortex (Braak and Braak, 1995), but fails to address whether TgF344-AD pathology emerges in other limbic regions such as the anterior thalamic nuclei or retrosplenial cortex. This is particularly important given cell types coding for head direction are found in both regions (Clark and Taube, 2012; Taube, 2007), and damage to both regions can produce deficits in the directional accuracy of navigation (Clark and Harvey, 2016; Harvey et al, 2017; Vann et al, 2009). Whether TgF344-AD rats exhibit AD pathology and disrupted spatial signaling in limbic-thalamic and limbic-cortical regions at early stages of development is unknown and warrants investigation.…”

Section: Discussionmentioning

confidence: 99%

Progressive impairment of directional and spatially precise trajectories by TgF344-AD Rats in the Morris Water Task

Berkowitz

Harvey

Drake

et al. 2018

Preprint

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6 7 8 Abstract 24Spatial navigation is impaired in early stages of Alzheimer's disease (AD), and 25 may be a defining behavioral marker of preclinical AD. Nevertheless, limitations of 26 diagnostic criteria for AD and within animal models of AD make characterization of 27 preclinical AD difficult. A new rat model (TgF344-AD) of AD overcomes many of these 28 limitations, though spatial navigation has not been comprehensively assessed. Using the 29 hidden and cued platform variants of the Morris water task, a longitudinal assessment of 30 spatial navigation was conducted on TgF344-AD (n=16) and Fischer 344 (n=12) male 31 and female rats at three age ranges: 4 to 5 months, 7 to 8, and 10 to 11 months of age. 32TgF344-AD rats exhibited largely intact navigation at 4-5 and 7-8 months of age, with 33 deficits in the hidden platform task emerging at 10-11 months of age. In general, TgF344-34 AD rats displayed less accurate swim trajectories to the platform and a wider search area 35 around the platform region compared to wildtype rats. Impaired navigation occurred in 36 the absence of deficits in acquiring the procedural task demands or navigation to the cued 37 platform location. Together, the results indicate that TgF344-AD rats exhibit comparable 38 deficits to those found in individuals in the early stages of AD. 39 40 41 42 43 44 45 46 47Alzheimer's disease (AD) is the most common form of dementia in the United 48 States and is characterized by progressive cognitive decline and neurodegeneration 49 (Association and others, 2017). AD pathology, marked by amyloid plaques and 50 neurofibrillary tangles that accumulate throughout the limbic system and hippocampus, is 51 predicted to initiate up to 20 years prior to the onset of behavioral symptoms (Gao et al., 52 1998; Mielke et al., 2014). Although the long preclinical period poses a significant 53 challenge to early diagnosis of AD (Dubois et al., 2016; Graham et al., 2017) subtle 54 changes in memory, as observed in amnestic mild cognitive impairment (aMCI), can 55 indicate an increased risk of progressing to dementia (Petersen, 2004; Winblad et al., 56 2004). However, because not all cases of aMCI progress to AD, there is a growing need 57 for sensitive behavioral assessments for AD diagnosis. 58Mounting evidence suggests that spatial disorientation, sometimes referred to as 59 wandering, are among the earliest memory complaints in AD (Bianchini et al., 2014; Bird 60 et al., 2010; Chan et al., 2016; Guariglia and Nitrini, 2009; Pai and Jacobs, 2004; Yew et 61 al., 2013). In general, disorientation is characterized as deficient localization of hidden 62 goals (Hort et al., 2007), a loss of direction sense (Cushman et al., 2008; deIpolyi et al., 63 2007; Monacelli et al., 2003; Tu et al., 2015), or an impairment in correctly identifying 64 familiar spatial scenes after a small change in view-point (Bird et al., 2010; Chan et al., 65 2016). Deficits in establishing or utilizing map-like (allocentric) frameworks for 66 navigation ...

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“…The direction of maximum response, or the preferred firing direction, varies between cells, such that a small population of HD cells can encode the full range of possible HDs. HD cells are found prominently in anterior thalamic nuclei (ATN), including the anterodorsal, anteroventral, and anteromedial thalamic nuclei (Taube, 1995;Tsanov et al, 2011;Jankowski et al, 2015; for review see Clark and Harvey, 2016); in parahippocampal regions such as the postsubiculum (PoS) (Taube et al, 1990a), medial entorhinal cortex (MEC), and parasubiculum (PaS) (Sargolini et al, 2006;Boccara et al, 2010); and in dorsal cortical regions such as the parietal cortex (PC) (Chen et al, 1994a,b;Wilber et al, 2014;reviewed in Clark et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Neural Decoding Methods and Population Coding Across Thalamo-Cortical Head Direction Cells

Winter

et al. 2019

Front. Neural Circuits

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Head direction (HD) cells, which fire action potentials whenever an animal points its head in a particular direction, are thought to subserve the animal's sense of spatial orientation. HD cells are found prominently in several thalamo-cortical regions including anterior thalamic nuclei, postsubiculum, medial entorhinal cortex, parasubiculum, and the parietal cortex. While a number of methods in neural decoding have been developed to assess the dynamics of spatial signals within thalamo-cortical regions, studies conducting a quantitative comparison of machine learning and statistical model-based decoding methods on HD cell activity are currently lacking. Here, we compare statistical model-based and machine learning approaches by assessing decoding accuracy and evaluate variables that contribute to population coding across thalamo-cortical HD cells.

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Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory?

Cited by 50 publications

References 90 publications

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris Water Task

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris Water Task

Progressive impairment of directional and spatially precise trajectories by TgF344-AD Rats in the Morris Water Task

A Comparison of Neural Decoding Methods and Population Coding Across Thalamo-Cortical Head Direction Cells

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