Single Nanoparticle Detection and Sizing Using a Nanofiber Pair in an Aqueous Environment

Yu, Xiaonan; Li, Beibei; Wang, Pan; Tong, Limin; Jiang, Xuefeng; Li, Yan; Gong, Qihuang; Xiao, Yun‐Feng

doi:10.1002/adma.201402085

Cited by 71 publications

(53 citation statements)

References 31 publications

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“…3f (Supplementary Information VI). Unlike previous experiments 14,15 which used a combination of repulsive electrostatic forces and attractive optical forces to trap larger particle near the nanofibre, we demonstrate theoretically and experimentally that optical attraction is negligible for our smaller particles (Supplementary Information VIII).…”

Section: Detection and Trapping Of Single Nanoparticlescontrasting

confidence: 52%

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Evanescent single-molecule biosensing with quantum-limited precision

et al. 2017

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Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits. Recently, exceptional sensitivity has been achieved using the strongly enhanced evanescent fields provided by optical microcavities and nano-sized plasmonic resonators. However, at high field intensities photodamage to the biological specimen becomes increasingly problematic. Here, we introduce an optical nanofibre based evanescent biosensor that operates at the fundamental precision limit introduced by quantisation of light. This allows a four order-of-magnitude reduction in optical intensity whilst maintaining state-of-the-art sensitivity. It enables quantum noise limited tracking of single biomolecules as small as 3.5 nm, and surface-molecule interactions to be monitored over extended periods. By achieving quantum noise limited precision, our approach provides a pathway towards quantum-enhanced single-molecule biosensors. IntroductionEvanescent optical biosensors that operate label-free and can resolve single molecules have applications ranging from clinical diagnostics 1 , to environmental monitoring 2, 3 and the detection and manipulation of viruses 4 , proteins and antibodies [5][6][7] . Further, they offer the prospect to provide new insights into motor molecule dynamics and biophysically important conformational changes as they occur in the natural state, unmodified by the presence of fluorescent markers or nanoparticle labels 5 . Recently, the reach of evanescent techniques has been extended to single proteins with Stokes radii of a few nanometers 1,6 by concentrating the optical field using resonant structures such as optical microcavities 2, 4, 5 and plasmonic resonators 1,6,7 . These advances illustrate a near-universal feature of precision opti- cal biosensors -that increased light intensities are required to detect smaller molecules or improve spatiotemporal resolution. This increases the photodamage experienced by the specimen, which can have broad consequences on viability 8 , function 9 , structure 10 and growth 11 . It is therefore desirable to develop alternative biosensing approaches that improve sensitivity without exposing the specimen to higher optical intensities.Here we demonstrate an optical nanofibre-based approach to evanescent detection and tracking of unlabelled biomolecules that utilises a combination of heterodyne interferometry and dark field illumination. This greatly suppresses technical noise due to background scatter, vibrations and laser fluctuations that has limited previous experiments 12,13 , allowing operation at the quantum noise limit to sensitivity introduced by the quantisation of light. The increased information that is extracted per scattered photon enables state-of-the-art sensitivity to be achieved with optical intensities four orders of magnitude lower than has been possible previously 1,6 . Using the biosensor, we detect nan...

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Section: Detection and Trapping Of Single Nanoparticlescontrasting

confidence: 52%

“…In contrast to previous approaches 14, 15 , we illuminate a small section of the nanofibre from above with a probe field. Since its propagation direction is orthogonal to the fibre axis, very little of the probe field is collected in the absence of nanoparticles and biomolecules.…”

Section: Dark-field Nanofibre Based Biosensormentioning

confidence: 99%

Evanescent single-molecule biosensing with quantum-limited precision

et al. 2017

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“…(5). (2) to be 30 (6) where, k spp =2πn eff /λ is the wave vector of the SPPs, and I 0 is initial intensity at the destructive interference as a reference or calibration (with a known concentration or refractive index). (2) to be 30 (6) where, k spp =2πn eff /λ is the wave vector of the SPPs, and I 0 is initial intensity at the destructive interference as a reference or calibration (with a known concentration or refractive index).…”

Section: Design and Principlementioning

confidence: 99%

“…[1][2][3] Optical sensors, a powerful detection and analysis tool, have been developed by using ring resonators, 4 waveguides, 5,6 and metallic structures based on surface plasmons (SPs). [1][2][3] Optical sensors, a powerful detection and analysis tool, have been developed by using ring resonators, 4 waveguides, 5,6 and metallic structures based on surface plasmons (SPs).…”

Section: Introductionmentioning

confidence: 99%

An ultrahigh-contrast and broadband on-chip refractive index sensor based on a surface-plasmon-polariton interferometer

Wang

Chen

Sun

et al. 2015

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Using a double-slit structure fabricated on a gold film or a subwavelength (300 nm) plasmonic waveguide, high-contrast and broadband plasmonic sensors based on the interference of surface plasmon polaritons (SPPs) are experimentally demonstrated on chips. By adjusting the focused spot position of the p-polarized incident light on the double-slit structure to compensate for the propagation loss of the SPPs, the interfering SPPs from the two slits have nearly equal intensities. As a result, nearly completely destructive interference can be experimentally achieved in a broad bandwidth (>200 nm), revealing the robust design and fabrication of the double-slit structure. More importantly, a high sensing figure of merit (FOM*) of >1 × 10(4) RIU(-1) (refractive index unit), which is much greater than the previous experimental results, is obtained at the destructive wavelength because of a high contrast ratio (C = 0.96). The high-contrast and broadband on-chip sensor fabricated on the subwavelength plasmonic waveguide may find important applications in the real-time sensing of particles and molecules.

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“…[17] To compensate for this, different kinds of approaches to enhancing the emission of monolayer MoS 2 are proposed, including chemical doping, [18] polymeric nano-spacing, [19] defect engineering, [20] and using surface plasmon polaritons (SPPs). [21][22][23] Among these methods, SPPs which have been widely utilized for strong light-matter interaction applications such as photoluminescence enhancement [24][25][26][27][28][29][30][31] and surface enhanced Raman scattering, [32,33] could induce hot electrons and cause the phase transition of MoS 2 , [34][35][36] resulting in the enhanced PL in a metal-MoS 2 coupled system. [37][38][39][40] For example, gap plasmons have been used in different areas, such as enhancing local chemical reactions, [41] dielectric gratings, [42,43] plasmonic nanocavities, [44][45][46] and PL of single layer WSe 2 .…”

Section: Introductionmentioning

confidence: 99%

Gap plasmon-enhanced photoluminescence of monolayer MoS ₂ in hybrid nanostructure

Liu

et al. 2018

Chinese Phys. B

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Monolayer transition-metal dichalcogenides (TMDs) have attracted a lot of attention for their applications in optics and optoelectronics. Molybdenum disulfide (MoS 2 ), as one of those important materials, has been widely investigated due to its direct band gap and photoluminescence (PL) in visible range. Owing to the fact that the monolayer MoS 2 suffers low light absorption and emission, surface plasmon polaritons (SPPs) are used to enhance both the excitation and emission efficiencies. Here, we demonstrate that the PL of MoS 2 sandwiched between 200-nm-diameter gold nanoparticle (AuNP) and 150-nm-thick gold film is improved by more than 4 times compared with bare MoS 2 sample. This study shows that gap plasmons can possess more optical and optoelectronic applications incorporating with many other emerging two-dimensional materials.

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Single Nanoparticle Detection and Sizing Using a Nanofiber Pair in an Aqueous Environment

Cited by 71 publications

References 31 publications

Evanescent single-molecule biosensing with quantum-limited precision

Evanescent single-molecule biosensing with quantum-limited precision

An ultrahigh-contrast and broadband on-chip refractive index sensor based on a surface-plasmon-polariton interferometer

Gap plasmon-enhanced photoluminescence of monolayer MoS ₂ in hybrid nanostructure

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Single Nanoparticle Detection and Sizing Using a Nanofiber Pair in an Aqueous Environment

Cited by 71 publications

References 31 publications

Evanescent single-molecule biosensing with quantum-limited precision

Evanescent single-molecule biosensing with quantum-limited precision

An ultrahigh-contrast and broadband on-chip refractive index sensor based on a surface-plasmon-polariton interferometer

Gap plasmon-enhanced photoluminescence of monolayer MoS 2 in hybrid nanostructure

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Gap plasmon-enhanced photoluminescence of monolayer MoS ₂ in hybrid nanostructure