“…In that respect several authors, including the corresponding author of this paper, related pharmacokinetic data of antibacterial agents in fish to the assumptions by Stamm (1989) and Shojaee AliAbadi & Lees (2000) with the aim of predicting clinical outcome of the treatment. Taking the plasma C 24 concentrations found in this study, a MIC value of 0.015 µg ml -1 determined by Samuelsen & Lunestad (1996) and a calculated AUC value of 533 mg h l -1 for flumequine in cod (Hansen & Horsberg 2000) in combination with the statements by Stamm (1989) and Shojaee AliAbadi & Lees (2000), it can be shown that all the doses of flumequine used in the present study fulfil the criteria (Table 1). A plot of the mean plasma concentrations against doses, excluding the 10 mg dose, shows a linear relationship (Fig.…”