Single dose oral paracetamol (acetaminophen) for postoperative pain in adults

Abstract

Background-This is an updated version of the original Cochrane review published in Issue 1, 2004 -this original review had been split from a previous title on 'Single dose paracetamol (acetaminophen) with and without codeine for postoperative pain'. The last version of this review concluded that paracetamol is an effective analgesic for postoperative pain, but additional trials have since been published. This review sought to evaluate the efficacy and safety of paracetamol using current data, and to compare the findings with other analgesics evaluated in the same way.

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Evaluation of the Impacts of Surgical Removal of Impacted Teeth on Alterations of the Mood With Beck Depression Inventory

“…However, the fact that this complication did not show a significant difference between the groups on the postoperative seventh day is consistent with other studies in the literature. [22][23][24][25] Postoperative swelling did not differ significantly on the postoperative seventh day, as did postoperative pain. Again, it did not have a significant effect on BDS scores on the seventh postoperative day.…”

Single dose oral fenoprofen for acute postoperative pain in adults

“…Indirect comparisons of NNTs for at least 50% pain relief over 4 to 6 hours in reviews of other analgesics using identical methods indicate that fenoprofen 200 mg is less effective than etoricoxib 120 mg (NNT 1.9 (1.7 to 2.1) Clarke 2009), but may have similar efficacy to commonly used analgesics such as ibuprofen 400 mg (2.5 (2.4 to 2.6) Derry C 2009a), naproxen 500 mg (2.7 (2.3 to 3.2) Derry C 2009b) or diclofenac 50 mg (2.7 (2.4 to 3.0) Derry P 2009). It appears to have better efficacy than paracetamol 1000 mg (3.6 (3.4 to 4.0) Toms 2008). However, the results for fenoprofen are based on relatively few studies with small numbers of participants, so the magnitude of the effect must be interpreted with caution.…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Evaluation of the Impacts of Surgical Removal of Impacted Teeth on Alterations of the Mood With Beck Depression Inventory

“…However, the fact that this complication did not show a significant difference between the groups on the postoperative seventh day is consistent with other studies in the literature. [22][23][24][25] Postoperative swelling did not differ significantly on the postoperative seventh day, as did postoperative pain. Again, it did not have a significant effect on BDS scores on the seventh postoperative day.…”

Single dose oral fenoprofen for acute postoperative pain in adults

“…Indirect comparisons of NNTs for at least 50% pain relief over 4 to 6 hours in reviews of other analgesics using identical methods indicate that fenoprofen 200 mg is less effective than etoricoxib 120 mg (NNT 1.9 (1.7 to 2.1) Clarke 2009), but may have similar efficacy to commonly used analgesics such as ibuprofen 400 mg (2.5 (2.4 to 2.6) Derry C 2009a), naproxen 500 mg (2.7 (2.3 to 3.2) Derry C 2009b) or diclofenac 50 mg (2.7 (2.4 to 3.0) Derry P 2009). It appears to have better efficacy than paracetamol 1000 mg (3.6 (3.4 to 4.0) Toms 2008). However, the results for fenoprofen are based on relatively few studies with small numbers of participants, so the magnitude of the effect must be interpreted with caution.…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Evaluation of the Impacts of Surgical Removal of Impacted Teeth on Alterations of the Mood With Beck Depression Inventory

“…However, the fact that this complication did not show a significant difference between the groups on the postoperative seventh day is consistent with other studies in the literature. [22][23][24][25] Postoperative swelling did not differ significantly on the postoperative seventh day, as did postoperative pain. Again, it did not have a significant effect on BDS scores on the seventh postoperative day.…”

Single dose oral fenoprofen for acute postoperative pain in adults

“…Indirect comparisons of NNTs for at least 50% pain relief over 4 to 6 hours in reviews of other analgesics using identical methods indicate that fenoprofen 200 mg is less effective than etoricoxib 120 mg (NNT 1.9 (1.7 to 2.1) Clarke 2009), but may have similar efficacy to commonly used analgesics such as ibuprofen 400 mg (2.5 (2.4 to 2.6) Derry C 2009a), naproxen 500 mg (2.7 (2.3 to 3.2) Derry C 2009b) or diclofenac 50 mg (2.7 (2.4 to 3.0) Derry P 2009). It appears to have better efficacy than paracetamol 1000 mg (3.6 (3.4 to 4.0) Toms 2008). However, the results for fenoprofen are based on relatively few studies with small numbers of participants, so the magnitude of the effect must be interpreted with caution.…”