Single-Dose Antibiotic Prophylaxis in Core Prostate Biopsy: Impact of Timing and Identification of Risk Factors

Lindstedt, Sandra; Lindström, Ulla; Ljunggren, Eva; Wullt, Björn; Grabe, Magnus

doi:10.1016/j.eururo.2006.05.003

Cited by 72 publications

(43 citation statements)

References 24 publications

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“…The cost of a routine bacterial culture was calculated by Lindstedt et al 10 as 8000 euros per 1000 cultures. This cost would likely increase if cultures were performed more routinely, especially given the increasing number of prostate biopsies performed each year.…”

Section: Discussionmentioning

confidence: 99%

Is urine culture routinely necessary before prostate biopsy?

Bruyère

d’Arcier

Boutin

et al. 2010

Prostate Cancer Prostatic Dis

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The objective of this study was to assess the value of a urine bacterial culture performed before prostate biopsy. We performed a prospective study on 353 patients who underwent prostate biopsy. All patients had a urine bacterial culture performed before biopsy. We compared the outcomes of patients with bacteriuria (left untreated) with those of patients without bacteriuria. Of the 353 men, 12 had a pre-biopsy-positive bacterial culture and underwent prostate biopsy without any infectious complication. Fifteen patients with a negative pre-biopsy culture developed a postbiopsy-positive bacterial culture, but remained asymptomatic without any treatment. Only four men from the group without pre-biopsy bacteriuria developed an infectious complication, requiring 3 weeks of antibiotic therapy. The complication rates were similar for both groups. Our results suggest that routine urine bacterial culture before prostate biopsy is not useful when antibiotic prophylaxis and enema are performed. We do, however, suggest performing a urine bacterial culture before prostate biopsy for patients with a previous history of urinary tract infections.

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Section: Discussionmentioning

confidence: 99%

Is urine culture routinely necessary before prostate biopsy?

Bruyère

d’Arcier

Boutin

et al. 2010

Prostate Cancer Prostatic Dis

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“…Therefore, prebiopsy urinalysis can reveal risk of infection. [24] In our study, in the presence of abnormal complete rutine urinalysis findings, and leukocyturia before biopsy, urine cultures were obtained to rule out bacteriuria. If bacterial growth was detected in prebiopsy urine cultures of the patients, then appropriate antibiotherapy was applied, and biopsy was postponed.…”

Section: Discussionmentioning

confidence: 99%

Comparison between ciprofloxacin and trimethoprim-sulfamethoxazole in antibiotic prophylaxis for transrectal prostate biopsy

Atılgan

Gençten

Kölükçü

et al. 2015

Turkish Journal of Urology

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Objective: The aim of this study was to compare the efficacies of oral ciprofloxacin administration and oral trimethoprim-sulfamethoxazole (TMP-SMX) regimens in preventing infectious complications following transrectal ultrasound guided biopsy of the prostate. Material and methods:Between 2011-2013, the medical records of 391 (mean age 64.62±7.64 years; range 40 to 87 years) patients who underwent transrectal prostate biopsies, due to suspicion of prostate cancer were retrospectively reviewed. While 500 mg ciprofloxacin was given orally twice daily starting one day before the procedure, continued for 3 days in the first 174 patients (group 1); was given orally twice daily starting one day before the procedure, continued for 3 days in the remaining 217 patients (group 2) for prophylaxis. Urine samples were obtained for urine culture before the procedure. The two groups were compared with respect to findings of urine cultures performed before and after the procedure and complications. Results:In the ciprofloxacin and groups, any positive urine culture before the procedure was not observed. Complications occured in 93 patients (37 in group 1 and 56 in group 2), after the procedure. Twenty-two (5.6%) (11 in group 1 and 11 in group 2). patients were admitted to our clinic because of high fever occurring after biopsy. Nine ciprofloxacin-treated (5.2%) and 16 TMP-SMX-treated (7.4%) patients had severe dysuria after the procedure. Twenty-one ciprofloxacin recipients (12.1%) and 40 TMP-SMX recipients (18.4%) had macroscopic hematuria. In the ciprofloxacin and TMP-SMX groups, the incidences of new culture positivity were 4% (n=7) and 2.8% (n=6) after the procedure, respectively. All of the isolated bacteria was Escherichia coli. While 11 patients were hospitalized due to signs of complicated urinary tract infections, and 2 patients were treated as outpatients. Rectal bleeding that did not require any intervention was observed in a patient 8 hours after biopsy. SIRS findings were detected in two patients. There were no significant differences between the two groups with respect to age, prostate volume, prostate spesific antigen (PSA) levels, and results of urine culture performed after the procedure (p>0.05). Conclusion:Despite the increasing resistance to antibiotics, ciprofloxacin and TMP-SMX are effective prophylactic treatment modalities for transrectal prostate biopsy. Both three-day ciprofloxacin and TMP-SMX regimens seem to be equally effective in the antibiotic prophylaxis for transrectal prostate biopsy.

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“…Lindstedt et al 26 , analizando específicamente el momento de administración del antibiótico (monodosis de ciprofloxacino por vía oral), no encontraron diferencias en la tasa de infecciones sintomáticas entre tomar el antibiótico 2 h antes o inmediatamente antes de la biopsia. Argyropoulos et al 27 , al comparar la administración de levofloxacino oral 30-60 min antes o inmediatamente después de la biopsia, tampoco apreciaron diferencias en las complicaciones infecciosas entre ambos grupos.…”

Section: Inicio De La Profilaxis Antibióticaunclassified

“…Argyropoulos et al 27 , al comparar la administración de levofloxacino oral 30-60 min antes o inmediatamente después de la biopsia, tampoco apreciaron diferencias en las complicaciones infecciosas entre ambos grupos. En la tabla 1 se recoge el momento en que inician la profilaxis oral diferentes autores y los porcentajes de infecciones sintomáticas observados 8,14,20,[26][27][28][29] .…”

Section: Inicio De La Profilaxis Antibióticaunclassified

“…No obstante, autores partidarios de la monodosis defienden que, en pacientes en especial situación de riesgo por presentar inmunosupresión, problemas de vaciamiento vesical o historia de infecciones urinarias, puede estar justificada la prolongación del tiempo de profilaxis e incluso la realización de urocultivos previos a la biopsia y el tratamiento de eventuales infecciones urinarias 26,[31][32][33] .…”

Section: Pauta Larga Corta O Monodosisunclassified

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