“…This procedure has several minor and major known complications including infection that manifests clinically as fever, chills and dysuria (1). Antibiotic premedication is used routinely to decrease this complication (2, 3, 4), but despite the use of antibiotics, infection develops in many patients with various degrees, from pyuria without clinical symptoms to life-threatening septicemia (5, 6, 7). Different additional methods have been studied for reducing the rate of infection following TRUS guided biopsy including the use of cleansing enema before the procedure (8, 9, 10, 11, 12, 13, 14, 15).…”