Single-DNA electron spin resonance spectroscopy in aqueous solutions

Shi, Fazhan; Kong, Fei; Zhao, Pengju; Zhang, Xiaojun; Chen, Ming; Chen, Sanyou; Zhang, Qi; Wang, Mengqi; Ye, Xiangyu; Wang, Zhecheng; Qin, Zhuoyang; Rong, Xing; Su, Ji‐Hu; Wang, Pengfei; Qin, Peter Z.; Du, Jiangfeng

doi:10.1038/s41592-018-0084-1

Cited by 74 publications

(58 citation statements)

References 21 publications

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“…Third, the current measurement is still time-consuming. The widely used nitroxide spin labels may be bleached during the strong laser illumination (7,8). A possible solution is improving the detection efficiency by implanting the spin-to-charge readout technique (37) or extending the lifetimes of spin labels by lowering the temperature and moving to a vacuum environment (8).…”

Section: Discussionmentioning

confidence: 99%

“…The P1 centers in diamond are ideal systems for demonstrations of this technique, while practical applications require target spins external to the diamond surface. Although this line-narrowing phenomenon also exists in many other paramagnetic materials, such as 15 N nitroxide spin labels ( 7 ) and some transition ions ( 25 , 26 ), the observations with NV centers are more challenging. First, fast diffusions of the target spins will cancel their dipolar couplings with the NV sensor in the absence of external magnetic field, making the detections impossible.…”

Section: Discussionmentioning

confidence: 99%

“…In the past decades, intensive efforts have been devoted to promote the spatial resolution, and ultimately, single-spin EPR has been realized by various approaches, such as magnetic resonance force microscopy (3), scanning tunneling microscopy (4), and nitrogen-vacancy (NV) center-based EPR spectroscopy (5)(6)(7). Among them, the NV center is more promising for biological applications because of the compatibility with ambient conditions (5)(6)(7). However, the current spectral resolution of those techniques is on the orders of megahertz (3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Among them, the NV center is more promising for biological applications because of the compatibility with ambient conditions (5)(6)(7). However, the current spectral resolution of those techniques is on the orders of megahertz (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). It is insufficient to resolve molecules of slightly different structures (13) or local polarity profiles (14).…”

Section: Introductionmentioning

confidence: 99%

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Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field

Kong

Zhao

et al. 2020

Sci. Adv.

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Electron paramagnetic resonance (EPR) spectroscopy is among the most important analytical tools in physics, chemistry, and biology. The emergence of nitrogen-vacancy (NV) centers in diamond, serving as an atomic-sized magnetometer, has promoted this technique to single-spin level, even under ambient conditions. Despite the enormous progress in spatial resolution, the current megahertz spectral resolution is still insufficient to resolve key heterogeneous molecular information. A major challenge is the short coherence times of the sample electron spins. Here, we address this challenge by using a magnetic noise–insensitive transition between states of different symmetry. We demonstrate a 27-fold narrower spectrum of single substitutional nitrogen (P1) centers in diamond with a linewidth of several kilohertz, and then some weak couplings can be resolved. Those results show both spatial and spectral advances of NV center–based EPR and provide a route toward analytical (EPR) spectroscopy at the single-molecule level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field

Kong

Zhao

et al. 2020

Sci. Adv.

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“…The NV center was created by nitrogen ion implantation [41] with an energy of 30 Kev. To improve the photon collection efficiency, a nanopillar structure [42,43] was fabricated. An external static magnetic field around 370 Gauss was applied to remove the degeneracy between m s = +1 and m s = −1.…”

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confidence: 99%

Experimental observation of dynamical bulk-surface correspondence in momentum space for topological phases

Wang

Chai

et al. 2019

Phys. Rev. A

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We experimentally demonstrate a dynamical classification approach for investigation of topological quantum phases using a solid-state spin system through nitrogen-vacancy (NV) center in diamond. Similar to the bulkboundary correspondence in real space at equilibrium, we observe a dynamical bulk-surface correspondence in the momentum space from a dynamical quench process. An emergent dynamical topological invariant is precisely measured in experiment by imaging the dynamical spin-textures on the recently defined band-inversion surfaces, with high topological numbers being implemented. Importantly, the dynamical classification approach is shown to be independent of quench ways and robust to the decoherence effects, offering a novel and practical strategy for dynamical topology characterization, especially for high dimensional gapped topological phases.The topology of quantum systems has been developed into a major focus of research in physics since the discovery of quantum Hall effect [1,2]. Beyond the states of quantum matter characterized by Landau symmetry-breaking theory, the topological quantum phases bear a myriad of properties depending only on the topology [3-5], with the most celebrated paradigms discovered recently including the topological insulators [6][7][8][9][10][11] and semimetals [12,13]. Among the many exotic features emerging in a topological matter, the bulk-boundary correspondence is the most fundamental phenomenon showing that on the boundary gapless states can be obtained corresponding to and protected by the nontrivial topology in the bulk [14,15].At equilibrium, the number of topologically protected surface (edge) states is uniquely related to the bulk topological invariants [14,15]. This allows to detect topological insulators [8][9][10][11] and semimetals [12,13] by resolving the surface states from transport measurement or angle resolved photoemission spectroscopy. Apart from the direct measurement in condensed matter physics, quantum simulation may provide new strategies for the characterization [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. For example, the band topology of 1D Su-Schrieffer-Heeger (SSH) chain can be determined by measuring the Zak phase [19,20], the bulk topology of a 2D Chern insulator can be observed by Hall transport studies [21,22], by Berry curvature mapping [27], or by a minimal measurement strategy [28] of imaging the spin texture at symmetric Bloch space [29]. In addition, these systems naturally offer powerful probes and controllability in comparison with their condensed matter counterpart, which enables the study of non-equilibrium physics across topological phase transitions. A generic protocol in state-of-the-art experiments is to prepare a topologically trivial initial state and then observe the non-equilibrium dynamics after the Hamiltonian has been quenched into a topological regime. For such non-equilibrium process, the bulk-boundary correspondence, however, is no-longer valid [30][31][32][33]. A natural challenge is to find a generic method ...

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Studying Ribozymes with Electron Paramagnetic Resonance Spectroscopy

Schiemann

2021

Ribozymes

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Single-DNA electron spin resonance spectroscopy in aqueous solutions

Cited by 74 publications

References 21 publications

Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field

Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field

Experimental observation of dynamical bulk-surface correspondence in momentum space for topological phases

Studying Ribozymes with Electron Paramagnetic Resonance Spectroscopy

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