Single crystal growth of water-soluble metal complexes with the help of the nano-crystallization method

Álvarez, Roberto; Nievergelt, Philipp P.; Slyshkina, Ekaterina; Müller, Péter; Alberto, Roger; Spingler, Bernhard

doi:10.1039/d0dt01236j

Cited by 5 publications

(4 citation statements)

References 71 publications

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“…Additionally, the cationic unit of tPt-Zn4PyP could be crystallized as the tetraphenylborate salt using the under-oil technique (see experimental part) and was studied by X-ray analysis (Figure 2). We are particularly pleased to obtain this structure, as this structure is the first example of expanding our robotic, aqueous crystallization trials [14][15]23 towards organic solvents. The zinc metal center is in a square pyramidal geometry with one DMF molecule as the fifth ligand.…”

Section: Resultsmentioning

confidence: 99%

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Rubbiani¹,

Wu²,

Naik³

et al. 2020

Preprint

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We report the synthesis of novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) for photodynamic therapy (PDT), their characterization, cellular uptake and localization, as well as the determination of their in vitro light-induced anticancer properties. The PSs show excellent phototoxic indexes up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, isotopic labelling of the porphyrin with a highly enriched 67Zn isotope was performed in order to determine the distribution ratio of zinc to platinum by ICP-MS, allowing to differentiate between naturally occurring zinc and 67Zn that was introduced into the cells by the PS. We conclude that the platinum units within the platinum-PS conjugates help to solubilize the PS and, at the same time, act as cell-penetrating vectors, enhancing the efficiency of the PS without causing a significant dark toxicity.

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Section: Resultsmentioning

confidence: 99%

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Rubbiani¹,

Wu²,

Naik³

et al. 2020

Preprint

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“…The technique utilizes an automated robotic dispenser for crystallization solution preparations with roughly ∼1 mg of analyte compound dissolved in a minimum buffer volume (∼100 μL) and predetermined 96−192 different crystallization reagent settings. Although regarded as a common practice for biochemical-oriented research, the feasibility of the method for inorganic coordination compound crystal growth was only recently illustrated by Springler et al 51 Their experience with the technique has led to the development of a widely available commercial crystallization screen that was also used for this study. 0.3 μL droplets of freshly prepared 20 mg/mL solution of U IV DOTAM in H 2 O were automatically dispensed in a 2-well MRC-2 96-well crystallization plate (SWISSCI) with a 1.5 M NaCl solution reservoir using the Formulatrix NT8 Drop Setter.…”

Section: ■ Experimental Methodsmentioning

confidence: 99%

Macrocyclic Ligand Coordinating Amide-Arm Hydrolysis Reaction Activation in Aqueous Solutions: Tetravalent Uranium Does It Better

Dovrat,

Pevzner,

Maimon

et al. 2023

Inorg. Chem.

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Chelation of lanthanide and actinide cations within a suitable macrocyclic ligand often results in a rigid, kinetically inert, and thermodynamically stable complex. A benchmark for such cation− ligand suitability are cyclen-derived macrocyclic ligands, frequently used as large cation hosts for various applications. Herein, a comprehensive study of the 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane ligand (DOTAM) chelates of U IV and Ce III and their properties in aqueous solutions is presented. By employing multiple analysis techniques, including X-ray crystallography, UV−vis absorbance, 1 H NMR, UPLC-MS, cyclic voltammetry, and differential pulse voltammetry, the study has revealed that the two aqueous complexes undergo a spontaneous, gradual, and stepwise hydrolysis of each of the coordinated amides toward carboxylates. The coordination of U IV in the studied reaction has been shown to significantly enhance the reaction rate, leading to an acceleration of up to 6 orders of magnitude compared to the natural process of simple aqueous amides at room temperature. An attempt to describe the unusual chelated metal cation amide-activation feature, based on the relatively lower rigidity of the complex structure, is presented. Additionally, the electrochemical properties of the complex series are discussed in detail, along with the limitations of the analytical methods employed.

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“…The micrographs presented the formation of crystals as the solution gradually reached supersaturation. Micrographs obtained using PTFE-20 (Figure 2A) presented needle-like orthorhombic crystals with possible elongation at higher process duration (t = 4 h) (Alvarez et al, 2020). Based on the microscopic image, the number of crystals forming increased linearly with time (Figures 2B,2).…”

Section: Microscopic Imagerymentioning

confidence: 95%

Resource recovery from acid mine drainage in membrane distillation crystallization

Chimanlal,

Nthunya,

Quist-Jensen

et al. 2023

Front. Membr. Sci. Technol.

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Acid mine drainage (AMD) remains a global threat with no exception to South African water bodies and the environment. It promotes environmental challenges with emerging concerns on water security and drinking water pollution. This study evaluated membrane distillation crystallization (MDC) towards resource recovery from AMD. To ensure high process performance, polyvinylidene fluoride (PVDF) membranes evaluated in the current study were modified using hydrophobic nanoparticle additives and compared with PTFE-20 reference membrane. The produced permeate flux of PTFE-20 reference membranes and M4 (fSiO2NPs-modified membrane) were 2.426 kg m-2·h-1 and 1.459 kg m-2·h-1, respectively. Similarly, salt rejections were 99.96% and 97.52%, respectively. Based on single crystal x-ray diffraction and scanning electron microscopy analysis, MDC predominantly produced monoclinic gypsum (CaSO4.2H2O) with the C2/c space group. Also, crystal properties obtained in fSiO2NPs-modified and PTFE-20 reference membranes were comparable. Though a considerable amount of gypsum was obtained, membrane surfaces were characterized by traces of salt deposit, with possible membrane scaling leading to performance deterioration. The permeate conductivity increased rapidly at the highest water recovery factor, indicating membrane wetting caused by scaling.

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Single crystal growth of water-soluble metal complexes with the help of the nano-crystallization method

Abstract:
Let pipetting robots set up nano crystallization trials of water-soluble metal complexes in order to obtain single crystals!

Cited by 5 publications

References 71 publications

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Macrocyclic Ligand Coordinating Amide-Arm Hydrolysis Reaction Activation in Aqueous Solutions: Tetravalent Uranium Does It Better

Resource recovery from acid mine drainage in membrane distillation crystallization

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Single crystal growth of water-soluble metal complexes with the help of the nano-crystallization method

Abstract: Let pipetting robots set up nano crystallization trials of water-soluble metal complexes in order to obtain single crystals!

Cited by 5 publications

References 71 publications

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins Using Isotope Labelling

Macrocyclic Ligand Coordinating Amide-Arm Hydrolysis Reaction Activation in Aqueous Solutions: Tetravalent Uranium Does It Better

Resource recovery from acid mine drainage in membrane distillation crystallization

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Resources

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Abstract:
Let pipetting robots set up nano crystallization trials of water-soluble metal complexes in order to obtain single crystals!