Single‐centre study reports a 84% five‐year overall survival rate for paediatric solid tumours

Teppo, Eero; Penttinen, Jarkko; Myöhänen, Outi; Vettenranta, Kim; Lohi, Olli

doi:10.1111/apa.13425

Cited by 3 publications

(4 citation statements)

References 12 publications

(25 reference statements)

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“…The overall range of diagnoses mirrored the transitional phase for the age group, with decreasing haematopoietic malignancies and increasing solid cancers. The 5‐year OS of 84% compared well with local and international studies of children and adolescents 2,5 . Males had more unfavourable outcomes, as they accounted for 81.3% of haematopoietic malignancies.…”

Section: All Subjects (%) Solid Haematopoietic Cnsmentioning

confidence: 65%

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Incidence and outcomes of cancer in 16‐ to 17‐year‐old adolescents

et al. 2021

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In Finland, the incidence of cancer in adolescents aged 15-19 years is 23 per 100,000. 1 The most common types include typical childhood cancers, such as leukaemia, lymphomas and brain tumours, and adult-type cancers, for instance, melanomas and thyroid cancer. 1 Survival rates for children and adolescents with cancer have improved significantly, but patients aged 15-39 years have poorer rates than children for several cancers that affect both groups. 2 Multinational and paediatric-type protocols have been successful in treating adolescents and young adults with acute lymphoblas-

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Section: All Subjects (%) Solid Haematopoietic Cnsmentioning

confidence: 65%

“…The 5‐year OS of 84% compared well with local and international studies of children and adolescents. 2 , 5 Males had more unfavourable outcomes, as they accounted for 81.3% of haematopoietic malignancies.…”

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confidence: 99%

Incidence and outcomes of cancer in 16‐ to 17‐year‐old adolescents

et al. 2021

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“…The population-based EUROCARE-5 project [55] running from 1999-2007 reported no significant difference in survival times among children with various solid tumors. Similarly, in a single-center study in Finland comparing the periods 1990-1999 and 2000-2015 [60], the authors reported no significant change in survival times even with the improvements in diagnosis and treatment. Contrarily, a report from the Swedish Childhood Solid Tumour Working Group [58] and the Texas Cancer Registry [61] showed significant improvements in survival times.…”

Section: Plos Onementioning

confidence: 92%

“…Contrarily, a report from the Swedish Childhood Solid Tumour Working Group [58] and the Texas Cancer Registry [61] showed significant improvements in survival times. Other factors such as cancer stage [60,61], the prognostic molecular and genetic basis of cancer [62,63], the availability of treatment modalities, and response to treatment can impact the survival outcomes of children with solid tumors. Patients with advanced-stage cancer usually have adverse outcomes.…”

Section: Plos Onementioning

confidence: 99%

Ambient air pollution as a time-varying covariate in the survival probability of childhood cancer patients in the upper Northern Thailand

Sathitsamitphong,

Chitapanarux,

Srikummoon

et al. 2024

PLoS ONE

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The objective of this study is to determine the possible association between exposure to air pollution and the risk of death from cancer during childhood in upper northern Thailand. Data were collected on children aged 0–15 years old diagnosed with cancer between January 2003 and December 2018 from the Chiang Mai Cancer Registry. Survival rates were determined by using Kaplan-Meier curves. Cox proportional hazard models were used to investigate associations of potential risk factors with the time-varying air pollution level on the risk of death. Of the 540 children with hematologic cancer, 199 died from any cause (overall mortality rate = 5.3 per 100 Person-Years of Follow-Up (PYFU); 95%CI = 4.6–6.0). Those aged less than one year old (adjusted hazard ratio [aHR] = 2.07; 95%CI = 1.25–3.45) or ten years old or more (aHR = 1.41; 95%CI = 1.04–1.91) at the time of diagnosis had a higher risk of death than those aged one to ten years old. Those diagnosed between 2003 and 2013 had an increased risk of death (aHR = 1.65; 95%CI = 1.13–2.42). Of the 499 children with solid tumors, 214 died from any cause (5.9 per 100 PYFU; 95%CI = 5.1–6.7). Only the cancer stage remained in the final model, with the metastatic cancer stage (HR = 2.26; 95%CI = 1.60–3.21) and the regional cancer stage (HR = 1.53; 95%CI = 1.07–2.19) both associated with an increased risk of death. No association was found between air pollution exposure and all-cause mortality for either type of cancer. A larger-scale analytical study might uncover such relationships.

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Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

Peinemann

Enk²,

Smith

2017

Cochrane Database of Systematic Reviews

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Single‐centre study reports a 84% five‐year overall survival rate for paediatric solid tumours

Abstract: The treatment results in our study are comparable with those previously published. A comprehensive local database allows for a timely follow-up of the characteristics and quality of treatment of childhood malignancies.

Cited by 3 publications

References 12 publications

Incidence and outcomes of cancer in 16‐ to 17‐year‐old adolescents

Incidence and outcomes of cancer in 16‐ to 17‐year‐old adolescents

Ambient air pollution as a time-varying covariate in the survival probability of childhood cancer patients in the upper Northern Thailand

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

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