Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

Peinemann, Frank; Enk, Heike; Smith, L. A.

doi:10.1002/14651858.cd008216.pub5

Cited by 17 publications

(6 citation statements)

References 96 publications

(4 reference statements)

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“…However, HDCT in patients with high-risk soft-tissue sarcomas results in no significant improvement in outcome compared with standard-dose chemotherapy. [17][18][19][20] De Giorgi et al have investigated HDCT in children with relapsed extragonadal GCT. 10 In this paper, 23 patients with extragonadal GCT,…”

Section: F I G U R E 2 Os Of Relapsed and Refractory Patientsmentioning

confidence: 99%

Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

Pasquale

D’Angelo²,

Crocoli

et al. 2019

Pediatric Blood & Cancer

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Background: Malignant germ cell tumors (GCTs) are a heterogeneous group of rare neoplasms in children. Optimal outcome is achieved with multimodal therapies for patients with both localized and advanced disease, especially after the introduction of platinum-based chemotherapy regimens. In this respect, data on salvage treatment for children with relapsed or platinum-refractory disease are still limited.Methods: Retrospective analysis of data regarding patients affected by malignant GCTs with platinum-refractory or relapsed disease after first-line treatment according to AIEOP TCGM 2004 protocol was conducted.Results: Twenty-one patients, 15 females and 6 males, were considered for the analysis. All 21 patients received second-line conventional chemotherapy (SLCT), two of these immediately after surgery for local relapse removal. Two patients showed a progression of disease during SLCT and died of disease shortly thereafter, whereas 19 patients were in partial remission (PR) or complete remission (CR) after SLCT. Treatment after SLCT consisted in surgery on residual tumor mass (9/19) followed by high dose of chemotherapy (HDCT) with autologous hematopoietic stem cell support (16/19). The overall survival (OS) and event-free survival of the whole populations are 71% and 66.6%, respectively. Platinum-refractory patients OS is 54.5% compared with 91.5% of the relapsed group. There were no treatment-related deaths. Conclusion:SLCT followed or not by HDCT is an effective salvage treatment for children with relapsed/refractory GCTs. However, the role of HDCT following SLCT needs to be further investigated, especially regarding the identification of specific patient subgroups, which can benefit from this more intensive treatment.

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Section: F I G U R E 2 Os Of Relapsed and Refractory Patientsmentioning

confidence: 99%

Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

Pasquale

D’Angelo²,

Crocoli

et al. 2019

Pediatric Blood & Cancer

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“…Autologous hematopoietic stem cell transplantation (ASCT) is widely used for the treatment of myeloma and lymphoma (20) as well as some solid tumours (21). ASCT patients are generally thought to have less viral infections than allo-SCT patients and, apart systematic CMV viraemia measurement, other herpesviruses are not regularly monitored in ASCT patients.…”

Section: Introductionmentioning

confidence: 99%

Human herpesvirus 6 infection after autologous stem cell transplantation: A multicenter prospective study in adult patients

Balsat

Pillet

Tavernier

et al. 2019

Journal of Infection

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Objectives: to prospectively evaluate the incidence and the clinical relevance on hematopoietic reconstitution of HHV-6 infection in autologous hematopoietic stem cell transplantation (ASCT) recipients.Methods: HHV-6 DNA load was measured in whole blood specimens once during the 7 days before stem cell re-infusion and once a week after transplantation until hematopoietic recovery. Active HHV-6 infection was defined by 2 consecutive positive DNA loads.Results: from July 2012 to February 2015, 196 adult patients undergoing ASCT were enrolled. Twenty-two (11.2%) patients developed active HHV-6 infection with a cumulative incidence of 19% at 40 days after transplantation. The onset of active HHV-6 infection occurred with a median of 13 days after stem cell re-infusion. HHV-6 infection was associated with an increased frequency of non-infectious complications (OR = 5.05; 95%CI 1.78-14.32; P<.001). Moreover, the severity of these non-infectious complications was higher in recipients exhibiting HHV-6 infection (OR = 4.62; 95%CI 1.32-16.2; p<.01). Delayed neutrophils 10 (IQR: 8-14) vs 8 (IQR: 6-11) days and platelets recoveries 15 (IQR: 11.8-18.5) vs 8 (IQR: 4-14) days were observed in patients with active HHV-6 infection compared to non-infected ones.Conclusions: in this study, 11.2% ASCT recipients presented active HHV-6 infection associated with significantly delayed hematologic reconstitution. Words: 199 Highlights:-Active HHV-6 infection occurred in 11.2% of autologous stem cell recipients -HHV-6 infection is associated to increased frequency of non-infectious complications

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“…In its 2011 version, the review contained 54 included studies, 401 excluded studies and 46 additional references (https ://doi.org/10.1002/14651 858.CD008 216.pub3). In the 2017 versionPeinemann et al (2017), this changed to 2 included studies, 65 excluded studies and 65 additional references (https ://doi.org/10.1002/14651 858.CD008 216.pub5).…”

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confidence: 99%

Studying review articles in scientometrics and beyond: a research agenda

Blümel

Schniedermann

2020

Scientometrics

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Review articles are an often neglected genre in scholarly communication. Though there was intense discussion about review articles in scientometrics in the 1970s and 1980s, we find less studies devoted to this genre within the last 20 years. Yet, recent discussions in other fields, such as linguistics, sociology or medicine imply that review articles are part of important debates about problems of research in academia, such as research quality or transparency. Against that background, the purpose of this paper is to review recent developments for the study of review articles in scientometrics and beyond, to discuss theoretical, conceptual and empirical accounts of how review articles can be defined, and to identify major methodological and conceptual challenges for studying review articles. Based on reviewing work and inputs received from of a workshop conducted at a Conference of the International Society of Informetrics in September 2019, we propose a research agenda for the study of review articles. We have identified six realms of study in this area: (1) the study of methodological caveats resulting from the usage of scholarly databases, (2) the study of field specific patterns of reception and usage of review articles, (3) the study of argumentative and textual structures of review articles, (4) the exploration of organizations and infrastructures for review articles, (5) the study of epistemic roles of review articles, and (6) the analysis of authorship patterns in review articles.

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Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

Abstract: Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma so tissue sarcomas.

Cited by 17 publications

References 96 publications

Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

Human herpesvirus 6 infection after autologous stem cell transplantation: A multicenter prospective study in adult patients

Studying review articles in scientometrics and beyond: a research agenda

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