Cystic fibrosis (CF) is a multisystem genetic disease with autosomal recessive inheritance. CF is a progressive and life-shortening disease characterized by recurrent lung infection, exocrine pancreatic insufficiency, malnutrition, growth and developmental delay. Since studies have shown that the course of the disease is better in cases diagnosed in the asymptomatic period, it has been included in newborn screening programs in many countries for early diagnosis. In this article, cystic fibrosis screening programs implemented will be discussed.