Single cell tells the developmental story

Zhan, Zhengyan; Xu, Xin; Fu, Yu

doi:10.1007/s11434-016-1153-4

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Previous research found that myostatin signaling reversed the insulin-like growth factor 1/phosphatidyl inositol 3-kinase/protein kinase B (IGF-1/PI3K/Akt) hypertrophy pathway by inhibiting AKT, allowing for increased expression of atrophy-related genes 27 , 28 . The mammalian target of rapamycin (mTOR) is an important downstream mediator in the PI3K/Akt signaling pathway, which plays a critical role in regulating cell proliferation, survival, mobility and angiogenesis 29 . In the present study, we found that the mRNA expression of IGF-1, PI3K, AKT and mTOR significantly increased in 2 PP than 10 PP in vivo and in vitro ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

Mussel Inspired Polynorepinephrine Functionalized Electrospun Polycaprolactone Microfibers for Muscle Regeneration

Liu

Zhou

et al. 2017

Sci Rep

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Electrospun scaffolds with excellent mechanical properties, high specific surface area and a commendable porous network are widely used in tissue engineering. Improving the hydrophilicity and cell adhesion of hydrophobic substrates is the key point to enhance the effectiveness of electrospun scaffolds. In this study, polycaprolactone (PCL) fibrous membranes with appropriate diameter were selected and coated by mussel-inspired poly norepinephrine (pNE). And norepinephrine is a catecholamine functioning as a hormone and neurotransmitter in the human brain. The membrane with smaller diameter fibers, a relative larger specific surface area and the suitable pNE functionalization provided more suitable microenvironment for cell adhesion and proliferation both in vitro and in vivo. The regenerated muscle layer can be integrated well with fibrous membranes and surrounding tissues at the impaired site and thus the mechanical strength reached the value of native tissue. The underlying molecular mechanism is mediated via inhibiting myostatin expression by PI3K/AKT/mTOR hypertrophy pathway. The properly functionalized fibrous membranes hold the potential for repairing muscle injuries. Our current work also provides an insight for rational design and development of better tissue engineering materials for skeletal muscle regeneration.

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Section: Resultsmentioning

confidence: 99%