Single-breath diffusing capacity and lung volumes in small laboratory mammals

Takezawa, Jun; Miller, Frederick J.; O’Neil, John J.

doi:10.1152/jappl.1980.48.6.1052

Cited by 108 publications

(40 citation statements)

References 0 publications

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“…Similar results have also been found in the hamster and dog O'Neil et al, 1980;Pushpakom, 1970;Koo et al, 1974;Sherter et al, 1974;Fedullo et al, 1980;Lucey et al, 1980;Snider et al, 1977).…”

Section: Significancesupporting

confidence: 64%

Respiratory Toxicology: 1981

Newton¹

1981

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Section: Significancesupporting

confidence: 64%

Respiratory Toxicology: 1981

Newton¹

1981

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“…Their trachea was intubated, and the animals were placed on a pressure ventilator (Kent Scientific, Litchfield, CT) at a respiratory rate of 120/min and a pressure limit of 12 cm H 2 O. The inspiratory capacity (IC) of each animal was estimated by inflation with air to a pressure equivalent to 20 cm H 2 O (29,30). The lungs were then inflated with a volume equal to IC of a gas mixture containing 0.3% CO, 0.3% methane, and 20% O 2 (the balance was N).…”

Section: Methodsmentioning

confidence: 99%

Structural and functional consequences of alveolar cell recognition by CD8(+) T lymphocytes in experimental lung disease.

Enelow¹,

Mohammed²,

Stoler³

et al. 1998

J. Clin. Invest.

104

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CD8ϩ T cells infiltrate the lung in many clinical conditions, particularly in interstitial lung disease. The role(s) that CD8 ϩ T cells might be playing in the pathogenesis of inflammatory lung disease is unclear at present, as is the direct contribution of CD8 ϩ T cell effector activities to lung injury. This report describes a transgenic model used to evaluate the impact, on respiratory structure and function, of CD8 ϩ T lymphocyte recognition of a target antigen expressed endogenously in alveolar epithelial cells. We found that adoptive transfer of cloned CD8 ϩ cytotoxic T lymphocytes (CTLs) specific for an alveolar neo-antigen (influenza hemagglutinin) leads to progressive lethal injury in transgenic mice, which dramatically affects lung structure and function. Transgenic recipients of CD8 ϩ CTLs exhibited tachypnea and progressive weight loss, becoming moribund over a period of several days. Concomitantly, the animals developed a progressive interstitial pneumonitis characterized initially by lymphocytic infiltration of alveolar walls and spaces, followed by an exuberant mononuclear cell infiltration that correlated with restrictive pulmonary mechanics and a progressive diffusion impairment. These results indicate that antigen-specific CD8 ϩ T cell recognition of an alveolar epithelial "autoantigen" is, in and of itself, sufficient to trigger an inflammatory cascade that results in the histological and physiological manifestations of interstitial pneumonia. ( J. Clin. Invest. 1998. 102:1653-1661.)

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“…Takezawa et al (20) used a modified single-breath method to measure DLco in rabbits (1.3-3.5 kg) which are comparable in weight to the piglets in this study. DLCO by their method was 0.52 ml/min/mm Hg/kg.…”

Section: Discussionmentioning

confidence: 84%

“…This technique has been used in large animals (dogs, sheep) as well as humans (3, 10, 11, 13, 16, 18, 19, 2 1). Presently, the measurement of these cardiopulmonary indices in human neonates, utilizing standard invasive techniques, is limited by the size of the vascular access, the necessity to repetitively disconnect the patient from a ventilator, and by the time required to make the measurements (20).…”

mentioning

confidence: 99%